The mutation G145S in PrfA, a key virulence regulator of Listeria monocytogenes, increases DNA-binding affinity by stabilizing the HTH motif - PubMed (original) (raw)

A hybrid sub-lineage of Listeria monocytogenes comprising hypervirulent isolates.

Yin Y, Yao H, Doijad S, Kong S, Shen Y, Cai X, Tan W, Wang Y, Feng Y, Ling Z, Wang G, Hu Y, Lian K, Sun X, Liu Y, Wang C, Jiao K, Liu G, Song R, Chen X, Pan Z, Loessner MJ, Chakraborty T, Jiao X. Yin Y, et al. Nat Commun. 2019 Sep 30;10(1):4283. doi: 10.1038/s41467-019-12072-1. Nat Commun. 2019. PMID: 31570766 Free PMC article.

Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.

Tran TT, Mathmann CD, Gatica-Andrades M, Rollo RF, Oelker M, Ljungberg JK, Nguyen TTK, Zamoshnikova A, Kummari LK, Wyer OJK, Irvine KM, Melo-Bolívar J, Gross A, Brown D, Mak JYW, Fairlie DP, Hansford KA, Cooper MA, Giri R, Schreiber V, Joseph SR, Simpson F, Barnett TC, Johansson J, Dankers W, Harris J, Wells TJ, Kapetanovic R, Sweet MJ, Latomanski EA, Newton HJ, Guérillot RJR, Hachani A, Stinear TP, Ong SY, Chandran Y, Hartland EL, Kobe B, Stow JL, Sauer-Eriksson AE, Begun J, Kling JC, Blumenthal A. Tran TT, et al. PLoS Pathog. 2022 Jan 10;18(1):e1010166. doi: 10.1371/journal.ppat.1010166. eCollection 2022 Jan. PLoS Pathog. 2022. PMID: 35007292 Free PMC article.