Corelease of dopamine and serotonin from striatal dopamine terminals - PubMed (original) (raw)
Corelease of dopamine and serotonin from striatal dopamine terminals
Fu-Ming Zhou et al. Neuron. 2005.
Free article
Abstract
The striatum receives rich dopaminergic and more moderate serotonergic innervation. After vesicular release, dopamine and serotonin (5-hydroxytryptamine, 5-HT) signaling is controlled by transporter-mediated reuptake. Dopamine is taken up by dopamine transporters (DATs), which are expressed at the highest density in the striatum. Although DATs also display a low affinity for 5-HT, that neurotransmitter is normally efficiently taken up by the 5-HT transporters. We found that when extracellular 5-HT is elevated by exogenous application or by using antidepressants (e.g., fluoxetine) to inhibit the 5-HT transporters, the extremely dense striatal DATs uptake 5-HT into dopamine terminals. Immunohistochemical results and measurements using fast cyclic voltammetry showed that elevated 5-HT is taken up by DATs into striatal dopamine terminals that subsequently release 5-HT and dopamine together. These results suggest that antidepressants that block serotonin transporters or other factors that elevate extracellular 5-HT alter the temporal and spatial relationship between dopamine and 5-HT signaling in the striatum.
Comment in
- Antidepressants and the monoamine masquerade.
Sulzer D, Edwards RH. Sulzer D, et al. Neuron. 2005 Apr 7;46(1):1-2. doi: 10.1016/j.neuron.2005.03.013. Neuron. 2005. PMID: 15820686 Review.
Similar articles
- Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum.
Naudon L, Leroux-Nicollet I, Boulay D, Costentin J. Naudon L, et al. J Neural Transm (Vienna). 2001;108(4):431-44. doi: 10.1007/s007020170064. J Neural Transm (Vienna). 2001. PMID: 11475010 - Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood.
Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Rüther E, Huether G. Moll GH, et al. Brain Res Dev Brain Res. 2000 Feb 7;119(2):251-7. doi: 10.1016/s0165-3806(99)00182-0. Brain Res Dev Brain Res. 2000. PMID: 10675775 - Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression.
Mathews TA, Fedele DE, Coppelli FM, Avila AM, Murphy DL, Andrews AM. Mathews TA, et al. J Neurosci Methods. 2004 Dec 30;140(1-2):169-81. doi: 10.1016/j.jneumeth.2004.05.017. J Neurosci Methods. 2004. PMID: 15589347 - Presynaptic control of serotonin on striatal dopamine function.
Navailles S, De Deurwaerdère P. Navailles S, et al. Psychopharmacology (Berl). 2011 Feb;213(2-3):213-42. doi: 10.1007/s00213-010-2029-y. Epub 2010 Oct 16. Psychopharmacology (Berl). 2011. PMID: 20953589 Review. - Direct dopamine terminal regulation by local striatal microcircuitry.
Nolan SO, Zachry JE, Johnson AR, Brady LJ, Siciliano CA, Calipari ES. Nolan SO, et al. J Neurochem. 2020 Dec;155(5):475-493. doi: 10.1111/jnc.15034. Epub 2020 Jun 19. J Neurochem. 2020. PMID: 32356315 Free PMC article. Review.
Cited by
- The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes.
Norrholm SD, Horton DB, Dwoskin LP. Norrholm SD, et al. Neuropharmacology. 2007 Dec;53(8):982-9. doi: 10.1016/j.neuropharm.2007.10.001. Epub 2007 Oct 7. Neuropharmacology. 2007. PMID: 18022203 Free PMC article. - Association between psychotropic medication and sleep microstructure: evidence from large population studies.
Hartmann S, Parrino L, Ensrud K, Stone KL, Redline S, Clark SR, Baumert M. Hartmann S, et al. J Clin Sleep Med. 2023 Mar 1;19(3):581-589. doi: 10.5664/jcsm.10394. J Clin Sleep Med. 2023. PMID: 36546402 Free PMC article. Clinical Trial. - Pharmacogenetics of antidepressants.
Crisafulli C, Fabbri C, Porcelli S, Drago A, Spina E, De Ronchi D, Serretti A. Crisafulli C, et al. Front Pharmacol. 2011 Feb 16;2:6. doi: 10.3389/fphar.2011.00006. eCollection 2011. Front Pharmacol. 2011. PMID: 21687501 Free PMC article. - Quantitative evaluation of serotonin release and clearance in Drosophila.
Borue X, Cooper S, Hirsh J, Condron B, Venton BJ. Borue X, et al. J Neurosci Methods. 2009 May 15;179(2):300-8. doi: 10.1016/j.jneumeth.2009.02.013. Epub 2009 Mar 4. J Neurosci Methods. 2009. PMID: 19428541 Free PMC article. - Locally administered low nicotine-induced neurotransmitter changes in areas of cognitive function.
Shearman E, Rossi S, Sershen H, Hashim A, Lajtha A. Shearman E, et al. Neurochem Res. 2005 Aug;30(8):1055-66. doi: 10.1007/s11064-005-7132-9. Neurochem Res. 2005. PMID: 16258855
Publication types
MeSH terms
Substances
Grants and funding
- R01 NS021229/NS/NINDS NIH HHS/United States
- DA017173/DA/NIDA NIH HHS/United States
- MH67119/MH/NIMH NIH HHS/United States
- DA09411/DA/NIDA NIH HHS/United States
- NS21229/NS/NINDS NIH HHS/United States
- NS048505/NS/NINDS NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources