Prefrontal phase locking to hippocampal theta oscillations - PubMed (original) (raw)
Comparative Study
. 2005 Apr 7;46(1):141-51.
doi: 10.1016/j.neuron.2005.02.028.
Affiliations
- PMID: 15820700
- DOI: 10.1016/j.neuron.2005.02.028
Free article
Comparative Study
Prefrontal phase locking to hippocampal theta oscillations
Athanassios G Siapas et al. Neuron. 2005.
Free article
Abstract
The interactions between cortical and hippocampal circuits are critical for memory formation, yet their basic organization at the neuronal network level is not well understood. Here, we demonstrate that a significant portion of neurons in the medial prefrontal cortex of freely behaving rats are phase locked to the hippocampal theta rhythm. In addition, we show that prefrontal neurons phase lock best to theta oscillations delayed by approximately 50 ms and confirm this hippocampo-prefrontal directionality and timing at the level of correlations between single cells. Finally, we find that phase locking of prefrontal cells is predicted by the presence of significant correlations with hippocampal cells at positive delays up to 150 ms. The theta-entrained activity across cortico-hippocampal circuits described here may be important for gating information flow and guiding the plastic changes that are believed to underlie the storage of information across these networks.
Similar articles
- Reading the hippocampal code by theta phase-locking.
Jensen O. Jensen O. Trends Cogn Sci. 2005 Dec;9(12):551-3. doi: 10.1016/j.tics.2005.10.003. Epub 2005 Nov 3. Trends Cogn Sci. 2005. PMID: 16271504 - Medial prefrontal cortex cells show dynamic modulation with the hippocampal theta rhythm dependent on behavior.
Hyman JM, Zilli EA, Paley AM, Hasselmo ME. Hyman JM, et al. Hippocampus. 2005;15(6):739-49. doi: 10.1002/hipo.20106. Hippocampus. 2005. PMID: 16015622 - Phase precession of medial prefrontal cortical activity relative to the hippocampal theta rhythm.
Jones MW, Wilson MA. Jones MW, et al. Hippocampus. 2005;15(7):867-73. doi: 10.1002/hipo.20119. Hippocampus. 2005. PMID: 16149084 - Hippocampo-prefrontal cortex pathway: anatomical and electrophysiological characteristics.
Thierry AM, Gioanni Y, Dégénétais E, Glowinski J. Thierry AM, et al. Hippocampus. 2000;10(4):411-9. doi: 10.1002/1098-1063(2000)10:4<411::AID-HIPO7>3.0.CO;2-A. Hippocampus. 2000. PMID: 10985280 Review.
Cited by
- Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory.
Zhang Y, Cao L, Varga V, Jing M, Karadas M, Li Y, Buzsáki G. Zhang Y, et al. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2016432118. doi: 10.1073/pnas.2016432118. Proc Natl Acad Sci U S A. 2021. PMID: 33833054 Free PMC article. - Dysregulation of Prefrontal Cortex-Mediated Slow-Evolving Limbic Dynamics Drives Stress-Induced Emotional Pathology.
Hultman R, Mague SD, Li Q, Katz BM, Michel N, Lin L, Wang J, David LK, Blount C, Chandy R, Carlson D, Ulrich K, Carin L, Dunson D, Kumar S, Deisseroth K, Moore SD, Dzirasa K. Hultman R, et al. Neuron. 2016 Jul 20;91(2):439-52. doi: 10.1016/j.neuron.2016.05.038. Epub 2016 Jun 23. Neuron. 2016. PMID: 27346529 Free PMC article. - Theta Band-Power Shapes Amyloid-Driven Longitudinal EEG Changes in Elderly Subjective Memory Complainers At-Risk for Alzheimer's Disease.
Spinelli G, Bakardjian H, Schwartz D, Potier MC, Habert MO, Levy M, Dubois B, George N; INSIGHT-preAD Study Group. Spinelli G, et al. J Alzheimers Dis. 2022;90(1):69-84. doi: 10.3233/JAD-220204. J Alzheimers Dis. 2022. PMID: 36057818 Free PMC article. - Delta frequency optogenetic stimulation of the thalamic nucleus reuniens is sufficient to produce working memory deficits: relevance to schizophrenia.
Duan AR, Varela C, Zhang Y, Shen Y, Xiong L, Wilson MA, Lisman J. Duan AR, et al. Biol Psychiatry. 2015 Jun 15;77(12):1098-107. doi: 10.1016/j.biopsych.2015.01.020. Epub 2015 Feb 28. Biol Psychiatry. 2015. PMID: 25891221 Free PMC article. Review. - Theta Rhythmic Clock-Like Activity of Single Units in the Mouse Hippocampus.
Zhang L, Ma X, Chen G, Barkai E, Lin L. Zhang L, et al. J Neurosci. 2016 Apr 20;36(16):4415-20. doi: 10.1523/JNEUROSCI.3851-15.2016. J Neurosci. 2016. PMID: 27098686 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources