T cell costimulation by chemokine receptors - PubMed (original) (raw)
doi: 10.1038/ni1191. Epub 2005 Apr 10.
Affiliations
- PMID: 15821738
- DOI: 10.1038/ni1191
T cell costimulation by chemokine receptors
Barbara Molon et al. Nat Immunol. 2005 May.
Abstract
Signals mediated by chemokine receptors may compete with T cell receptor stop signals and determine the duration of T cell-antigen-presenting cell interactions. Here we show that during T cell stimulation by antigen-presenting cells, T cell chemokine receptors coupled to G(q) and/or G(11) protein were recruited to the immunological synapse by a G(i)-independent mechanism. When chemokine receptors were sequestered at the immunological synapse, T cells became insensitive to chemotactic gradients, formed more stable conjugates and finally responded with enhanced proliferation and cytokine production. We suggest that chemokine receptor trapping at the immunological synapse enhances T cell activation by improving T cell-antigen-presenting cell attraction and impeding the 'distraction' of successfully engaged T cells by other chemokine sources.
Comment in
- Chemokines as immunotransmitters?
Trautmann A. Trautmann A. Nat Immunol. 2005 May;6(5):427-8. doi: 10.1038/ni0505-427. Nat Immunol. 2005. PMID: 15843794 No abstract available.
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