Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis - PubMed (original) (raw)
Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis
Christina Sobin et al. Child Neuropsychol. 2005 Feb.
Abstract
Previous reports of cognitive functioning in children with the 22q11 Deletion Syndrome have reported marked variability in IQ and achievement subtest scores. Studies have begun to explore neuropsychological function in 22q11 DS however results are inconsistent and the profile incomplete. We assessed 40 children ages 5-12 with 22q11 DS. Consistent with past results, visual-spatial memory was significantly lower than verbal memory. Differentially lowered scores were found only in visual attention, working memory and motor function. Contrary with some past results quantitative, verbal ability, and visual spatial memory scores were within 1 SD from the standardization sample mean. Motor behavior, not typically discussed with regard to 22q11 DS school-age children, may be critical to incorporate in neurocognitive studies of children with 22q11 DS. Implications of these findings are considered with regard to past results.
Similar articles
- Atypical neuropsychological profile in a boy with 22q11.2 Deletion Syndrome.
Stiers P, Swillen A, De Smedt B, Lagae L, Devriendt K, D'Agostino E, Sunaert S, Fryns AP. Stiers P, et al. Child Neuropsychol. 2005 Feb;11(1):87-108. doi: 10.1080/09297040590911220. Child Neuropsychol. 2005. PMID: 15823985 - Memory and learning in children with 22q11.2 deletion syndrome: evidence for ventral and dorsal stream disruption?
Lajiness-O'Neill RR, Beaulieu I, Titus JB, Asamoah A, Bigler ED, Bawle EV, Pollack R. Lajiness-O'Neill RR, et al. Child Neuropsychol. 2005 Feb;11(1):55-71. doi: 10.1080/09297040590911202. Child Neuropsychol. 2005. PMID: 15823983 - Neuropsychological profile and neuroimaging in patients with 22Q11.2 Deletion Syndrome: a review.
Zinkstok J, van Amelsvoort T. Zinkstok J, et al. Child Neuropsychol. 2005 Feb;11(1):21-37. doi: 10.1080/09297040590911194. Child Neuropsychol. 2005. PMID: 15823981 Review. - Gender-moderated dorsolateral prefrontal reductions in 22q11.2 Deletion Syndrome: implications for risk for schizophrenia.
Kates WR, Antshel K, Willhite R, Bessette BA, AbdulSabur N, Higgins AM. Kates WR, et al. Child Neuropsychol. 2005 Feb;11(1):73-85. doi: 10.1080/09297040590911211. Child Neuropsychol. 2005. PMID: 15823984 - 22q11.2 deletion syndrome: genetics, neuroanatomy and cognitive/behavioral features keywords.
Antshel KM, Kates WR, Roizen N, Fremont W, Shprintzen RJ. Antshel KM, et al. Child Neuropsychol. 2005 Feb;11(1):5-19. doi: 10.1080/09297040590911185. Child Neuropsychol. 2005. PMID: 15823980 Review.
Cited by
- Distinct neuroanatomical and neuropsychological features of Down syndrome compared to related neurodevelopmental disorders: a systematic review.
Hamadelseed O, Chan MKS, Wong MBF, Skutella T. Hamadelseed O, et al. Front Neurosci. 2023 Aug 3;17:1225228. doi: 10.3389/fnins.2023.1225228. eCollection 2023. Front Neurosci. 2023. PMID: 37600012 Free PMC article. - Structural Connectivity and Emotion Recognition Impairment in Children and Adolescents with Chromosome 22q11.2 Deletion Syndrome.
Sanders AFP, Hobbs DA, Knaus TA, Beaton EA. Sanders AFP, et al. J Autism Dev Disord. 2023 Oct;53(10):4021-4034. doi: 10.1007/s10803-022-05675-z. Epub 2022 Aug 2. J Autism Dev Disord. 2023. PMID: 35917023 Free PMC article. - Altered developmental trajectories of verbal learning skills in 22q11.2DS: associations with hippocampal development and psychosis.
Latrèche C, Maeder J, Mancini V, Bortolin K, Schneider M, Eliez S. Latrèche C, et al. Psychol Med. 2023 Aug;53(11):4923-4932. doi: 10.1017/S0033291722001842. Epub 2022 Jul 1. Psychol Med. 2023. PMID: 35775360 Free PMC article. - Recognition of facial emotion expressions and perceptual processes in 22q11.2 deletion syndrome.
Buzzanca A, Accinni T, Frascarelli M, Troisi E, Kotzalidis GD, Di Bonaventura C, Fanella M, Putotto C, Marino B, Pasquini M, Biondi M, Di Fabio F. Buzzanca A, et al. Early Interv Psychiatry. 2023 Jan;17(1):76-84. doi: 10.1111/eip.13295. Epub 2022 Mar 28. Early Interv Psychiatry. 2023. PMID: 35347860 Free PMC article. - Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders.
Jalal R, Nair A, Lin A, Eckfeld A, Kushan L, Zinberg J, Karlsgodt KH, Cannon TD, Bearden CE. Jalal R, et al. J Neurodev Disord. 2021 Apr 17;13(1):15. doi: 10.1186/s11689-021-09363-4. J Neurodev Disord. 2021. PMID: 33863277 Free PMC article.
References
- Bearden CE, Woodin MF, Wang PP, Moss E, McDonald-McGinn D, Zackai E, Emmanuel B, Cannon TD. The neurocognitive phenotype of the 22q11.2 deletion syndrome: Selective deficit in visual-spatial memory. Journal of Clinical and Experimental Neuropsychology. 2001;23:447–464. - PubMed
- Berninger VW, Rutberg J. Relationship of finger function to beginning writing: Application to diagnosis of writing disabilities. Developmental Medicine and Child Neurology. 1992;34:198–215. - PubMed
- Buchanan L, Pavlovic J, Rovert J. The contribution of visuospatial working memory to impairments in facial processing and arithmetic in Turner syndrome. Brain and Cognition. 1998;37:72–75.
- Cohen MJ. Children’s Memory Scale. Psychological Corporation, Harcourt Brace & Company; San Antonio, TX: 1997.
- Courtney SM, Ungerleider LG, Keil K, Haxby JV. Object and spatial visual working memory activate separate neural systems in human cortex. Cerebral Cortex. 1996;6:39–49. - PubMed
Publication types
MeSH terms
Grants and funding
- K08 HD040321/HD/NICHD NIH HHS/United States
- M01 RR000102/RR/NCRR NIH HHS/United States
- K08 HD040321-05/HD/NICHD NIH HHS/United States
- K08-HD040321/HD/NICHD NIH HHS/United States
- M01-RR00102/RR/NCRR NIH HHS/United States
LinkOut - more resources
Full Text Sources
Miscellaneous