Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China - PubMed (original) (raw)
Affiliations
- PMID: 15827277
Decreased prevalence of the Plasmodium falciparum chloroquine resistance transporter 76T marker associated with cessation of chloroquine use against P. falciparum malaria in Hainan, People's Republic of China
Xinhua Wang et al. Am J Trop Med Hyg. 2005 Apr.
Abstract
The use of chloroquine treatment for Plasmodium falciparum malaria was abandoned in China in 1979 because of widespread drug resistance. Subsequent studies found decreases in the prevalence of chloroquine-resistant strains. To evaluate these decreases and assess the current status of chloroquine sensitivity in Hainan, China, we determined the prevalence of the P. falciparum chloroquine resistance transporter (PfCRT) 76T marker in the DNA of blood samples collected from 1978 to 2001. Results showed the presence of PfCRT 76T in 101 of 112 samples (90%) from 1978 to 1981, 30 of 43 samples (70%) from 1986, 22 of 34 samples (65%) from 1997 to 1998, and 37 of 68 samples (54%) from 2001. The prevalence of PfCRT 76T thus progressively decreased after chloroquine was discontinued as a treatment for P. falciparum malaria (chi(2) = 5.2, P < 0.022 [1978-1981 versus 1986]; chi(2) = 7.4, P < 0.006 [1978-1981 versus 1997-1998]; and chi(2) = 28.8, P < 0.0001 [1978-1981 versus 2001]). Reduced prevalence of the PfCRT 76T marker is consistent with greater rates of chloroquine sensitivity from in vitro drug assays of blood samples in 1997 and 2001. Monitoring for continued decreases will provide valuable information for future drug-use policies in China.
Similar articles
- [The point mutations in Pfcrt and Pfmdr1 genes in Plasmodium falciparum isolated from Hainan Province].
Guan YY, Tang LH, Hu L, Feng XP, Liu DQ. Guan YY, et al. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2005 Jun 30;23(3):135-9. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2005. PMID: 16299999 Chinese. - New haplotypes of the Plasmodium falciparum chloroquine resistance transporter (pfcrt) gene among chloroquine-resistant parasite isolates.
Nagesha HS, Casey GJ, Rieckmann KH, Fryauff DJ, Laksana BS, Reeder JC, Maguire JD, Baird JK. Nagesha HS, et al. Am J Trop Med Hyg. 2003 Apr;68(4):398-402. Am J Trop Med Hyg. 2003. PMID: 12875286 - Molecular assessment of Plasmodium falciparum resistance to antimalarial drugs in China.
Zhang GQ, Guan YY, Zheng B, Wu S, Tang LH. Zhang GQ, et al. Trop Med Int Health. 2009 Oct;14(10):1266-71. doi: 10.1111/j.1365-3156.2009.02342.x. Trop Med Int Health. 2009. PMID: 19772548 - pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.
Cooper RA, Hartwig CL, Ferdig MT. Cooper RA, et al. Acta Trop. 2005 Jun;94(3):170-80. doi: 10.1016/j.actatropica.2005.04.004. Acta Trop. 2005. PMID: 15866507 Review. - Chloroquine-resistant malaria.
Wellems TE, Plowe CV. Wellems TE, et al. J Infect Dis. 2001 Sep 15;184(6):770-6. doi: 10.1086/322858. Epub 2001 Aug 7. J Infect Dis. 2001. PMID: 11517439 Review.
Cited by
- Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.
Richards SN, Nash MN, Baker ES, Webster MW, Lehane AM, Shafik SH, Martin RE. Richards SN, et al. PLoS Pathog. 2016 Jul 21;12(7):e1005725. doi: 10.1371/journal.ppat.1005725. eCollection 2016 Jul. PLoS Pathog. 2016. PMID: 27441371 Free PMC article. - Monitoring Plasmodium falciparum chloroquine resistance in Yunnan Province, China, 1981-2006.
Yang H, Yang Y, Yang P, Li X, Gao B, Zhang Z, Yang Z, Cui L. Yang H, et al. Acta Trop. 2008 Oct;108(1):44-9. doi: 10.1016/j.actatropica.2008.08.010. Epub 2008 Sep 6. Acta Trop. 2008. PMID: 18822265 Free PMC article. - Factors associated with regional bias of pfcrt (plasmodium falciparum chloroquine resistance transporter) haplotypes in Nepal.
Banjara MR, Imwong M, Petmitr S, Sirawaraporn W, Joshi AB, Chavalitshewinkoon-Petmitr P. Banjara MR, et al. Southeast Asian J Trop Med Public Health. 2011 Jan;42(1):1-8. Southeast Asian J Trop Med Public Health. 2011. PMID: 21323158 Free PMC article. - Malaria on the Guiana Shield: a review of the situation in French Guiana.
Musset L, Pelleau S, Girod R, Ardillon V, Carvalho L, Dusfour I, Gomes MS, Djossou F, Legrand E. Musset L, et al. Mem Inst Oswaldo Cruz. 2014 Aug;109(5):525-33. doi: 10.1590/0074-0276140031. Epub 2014 Aug 13. Mem Inst Oswaldo Cruz. 2014. PMID: 25184998 Free PMC article. - Distribution patterns of molecular markers of antimalarial drug resistance in Plasmodium falciparum isolates on the Thai-Myanmar border during the periods of 1993-1998 and 2002-2008.
Muhamad P, Phompradit P, Chaijaroenkul W, Na-Bangchang K. Muhamad P, et al. BMC Genomics. 2024 Mar 11;25(1):269. doi: 10.1186/s12864-023-09814-3. BMC Genomics. 2024. PMID: 38468205 Free PMC article.