Wnt signalling in stem cells and cancer - PubMed (original) (raw)
Review
. 2005 Apr 14;434(7035):843-50.
doi: 10.1038/nature03319.
Affiliations
- PMID: 15829953
- DOI: 10.1038/nature03319
Review
Wnt signalling in stem cells and cancer
Tannishtha Reya et al. Nature. 2005.
Abstract
The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues, activation of Wnt signalling has also been associated with cancer. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signalling in stem and progenitor cells is subverted in cancer cells to allow malignant proliferation. Insights gained from understanding how the Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and growth in the intestinal, epidermal and haematopoietic systems may serve as a paradigm for understanding the dual nature of self-renewal signals.
Similar articles
- WNT signalling and haematopoiesis: a WNT-WNT situation.
Staal FJ, Clevers HC. Staal FJ, et al. Nat Rev Immunol. 2005 Jan;5(1):21-30. doi: 10.1038/nri1529. Nat Rev Immunol. 2005. PMID: 15630426 Review. - Wnt signaling and the regulation of stem cell function.
Kléber M, Sommer L. Kléber M, et al. Curr Opin Cell Biol. 2004 Dec;16(6):681-7. doi: 10.1016/j.ceb.2004.08.006. Curr Opin Cell Biol. 2004. PMID: 15530781 Review. - Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance.
Duncan AW, Rattis FM, DiMascio LN, Congdon KL, Pazianos G, Zhao C, Yoon K, Cook JM, Willert K, Gaiano N, Reya T. Duncan AW, et al. Nat Immunol. 2005 Mar;6(3):314-22. doi: 10.1038/ni1164. Epub 2005 Jan 23. Nat Immunol. 2005. PMID: 15665828 - Wnt signaling in stem and cancer stem cells.
Holland JD, Klaus A, Garratt AN, Birchmeier W. Holland JD, et al. Curr Opin Cell Biol. 2013 Apr;25(2):254-64. doi: 10.1016/j.ceb.2013.01.004. Epub 2013 Jan 21. Curr Opin Cell Biol. 2013. PMID: 23347562 Review. - Tissue repair and stem cell renewal in carcinogenesis.
Beachy PA, Karhadkar SS, Berman DM. Beachy PA, et al. Nature. 2004 Nov 18;432(7015):324-31. doi: 10.1038/nature03100. Nature. 2004. PMID: 15549094 Review.
Cited by
- Harnessing the role of aberrant cell signaling pathways in glioblastoma multiforme: a prospect towards the targeted therapy.
Hasan S, Mahmud Z, Hossain M, Islam S. Hasan S, et al. Mol Biol Rep. 2024 Oct 19;51(1):1069. doi: 10.1007/s11033-024-09996-3. Mol Biol Rep. 2024. PMID: 39424705 Review. - Transformation of macrophages into myofibroblasts in fibrosis-related diseases: emerging biological concepts and potential mechanism.
Li X, Liu Y, Tang Y, Xia Z. Li X, et al. Front Immunol. 2024 Sep 25;15:1474688. doi: 10.3389/fimmu.2024.1474688. eCollection 2024. Front Immunol. 2024. PMID: 39386212 Free PMC article. Review. - Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives.
Sat-Muñoz D, Balderas-Peña LM, Gómez-Sánchez E, Martínez-Herrera BE, Trujillo-Hernández B, Quiroga-Morales LA, Salazar-Páramo M, Dávalos-Rodríguez IP, Nuño-Guzmán CM, Velázquez-Flores MC, Ochoa-Plascencia MR, Muciño-Hernández MI, Isiordia-Espinoza MA, Mireles-Ramírez MA, Hernández-Salazar E. Sat-Muñoz D, et al. Int J Mol Sci. 2024 Sep 16;25(18):9979. doi: 10.3390/ijms25189979. Int J Mol Sci. 2024. PMID: 39337467 Free PMC article. Review. - NDR1/FBXO11 promotes phosphorylation-mediated ubiquitination of β-catenin to suppress metastasis in prostate cancer.
Xuan Z, Chen C, Sun H, Yang K, Li J, Fu M, Bai Y, Zheng Z, Zhao Y, Xu C, Liu B, Li T, Shao C. Xuan Z, et al. Int J Biol Sci. 2024 Sep 16;20(12):4957-4977. doi: 10.7150/ijbs.98907. eCollection 2024. Int J Biol Sci. 2024. PMID: 39309441 Free PMC article. - The antifibrotic potential of IMT504: modulation of GLAST + Wnt1 + bone marrow stromal progenitors and hepatic microenvironment.
Borda M, Sierra R, Cantero MJ, Gómez Bustillo S, Fiore EJ, Giardelli G, Martino Garcet M, Rebottaro ML, Bayo Fina JM, Schiavone M, Rubione J, García MG, Montaner A, Mazzolini GD, Aquino JB. Borda M, et al. Stem Cell Res Ther. 2024 Sep 4;15(1):278. doi: 10.1186/s13287-024-03896-w. Stem Cell Res Ther. 2024. PMID: 39227908 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases