LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function - PubMed (original) (raw)
. 2005 Jun 17;280(24):23024-31.
doi: 10.1074/jbc.M412564200. Epub 2005 Apr 13.
Affiliations
- PMID: 15831500
- DOI: 10.1074/jbc.M412564200
Free article
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function
Isabelle Gerin et al. J Biol Chem. 2005.
Free article
Abstract
Liver X receptors (LXR) alpha and beta are nuclear oxysterol receptors with established roles in cholesterol, lipid, and carbohydrate metabolism. Although LXRs have been extensively studied in liver and macrophages, the importance for development and metabolism of other tissues and cell types is not as well characterized. We demonstrate here that although LXRalpha and LXRbeta are not required for adipocyte development per se, LXRbeta is required for the increase in adipocyte size that normally occurs with aging and diet-induced obesity. Similar food intake and oxygen consumption in LXRbeta-/- mice suggests that reduced storage of lipid in adipose tissue is not due to altered energy balance. Despite reduced amounts of adipose tissue, LXRbeta-/- mice on a chow diet have insulin sensitivity and levels of adipocyte hormones similar to wild type mice. However, these mice are glucose-intolerant due to impaired glucose-induced insulin secretion. Lipid droplets in pancreatic islets may result from accumulation of cholesterol esters as analysis of islet gene expression reveals that LXRbeta is required for expression of the cholesterol transporters, ABCA1 and ABCG1. Our data establish novel roles for LXRbeta in adipocyte growth, glucose homeostasis, and beta cell function.
Similar articles
- Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.
Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P. Quinet EM, et al. Mol Pharmacol. 2006 Oct;70(4):1340-9. doi: 10.1124/mol.106.022608. Epub 2006 Jul 6. Mol Pharmacol. 2006. PMID: 16825483 - LXR is crucial in lipid metabolism.
Ulven SM, Dalen KT, Gustafsson JA, Nebb HI. Ulven SM, et al. Prostaglandins Leukot Essent Fatty Acids. 2005 Jul;73(1):59-63. doi: 10.1016/j.plefa.2005.04.009. Prostaglandins Leukot Essent Fatty Acids. 2005. PMID: 15913974 Review. - Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue.
Ulven SM, Dalen KT, Gustafsson JA, Nebb HI. Ulven SM, et al. J Lipid Res. 2004 Nov;45(11):2052-62. doi: 10.1194/jlr.M400119-JLR200. Epub 2004 Aug 1. J Lipid Res. 2004. PMID: 15292368 - Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice.
Korach-André M, Parini P, Larsson L, Arner A, Steffensen KR, Gustafsson JA. Korach-André M, et al. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E167-78. doi: 10.1152/ajpendo.00184.2009. Epub 2009 Aug 18. Am J Physiol Endocrinol Metab. 2010. PMID: 19690071 - Minireview: liver X receptor beta: emerging roles in physiology and diseases.
Gabbi C, Warner M, Gustafsson JA. Gabbi C, et al. Mol Endocrinol. 2009 Feb;23(2):129-36. doi: 10.1210/me.2008-0398. Epub 2008 Dec 12. Mol Endocrinol. 2009. PMID: 19074550 Free PMC article. Review.
Cited by
- Cholesterol Redistribution in Pancreatic β-Cells: A Flexible Path to Regulate Insulin Secretion.
Galli A, Arunagiri A, Dule N, Castagna M, Marciani P, Perego C. Galli A, et al. Biomolecules. 2023 Jan 24;13(2):224. doi: 10.3390/biom13020224. Biomolecules. 2023. PMID: 36830593 Free PMC article. Review. - Adapting Physiology in Functional Human Islet Organogenesis.
Yoshihara E. Yoshihara E. Front Cell Dev Biol. 2022 Apr 26;10:854604. doi: 10.3389/fcell.2022.854604. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 35557947 Free PMC article. - Obesity I: Overview and molecular and biochemical mechanisms.
Lustig RH, Collier D, Kassotis C, Roepke TA, Kim MJ, Blanc E, Barouki R, Bansal A, Cave MC, Chatterjee S, Choudhury M, Gilbertson M, Lagadic-Gossmann D, Howard S, Lind L, Tomlinson CR, Vondracek J, Heindel JJ. Lustig RH, et al. Biochem Pharmacol. 2022 May;199:115012. doi: 10.1016/j.bcp.2022.115012. Epub 2022 Apr 5. Biochem Pharmacol. 2022. PMID: 35393120 Free PMC article. Review. - The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD.
Dixon ED, Nardo AD, Claudel T, Trauner M. Dixon ED, et al. Genes (Basel). 2021 Apr 26;12(5):645. doi: 10.3390/genes12050645. Genes (Basel). 2021. PMID: 33926085 Free PMC article. Review. - [Exenatide promotes cholesterol efflux in pancreatic tissue of obese diabetic rats].
Zhao L, Zhang X, Feng J, Xiao Z, Liu Y, Long H, Chen X, Tang W. Zhao L, et al. Nan Fang Yi Ke Da Xue Xue Bao. 2021 Mar 25;41(3):370-375. doi: 10.12122/j.issn.1673-4254.2021.03.08. Nan Fang Yi Ke Da Xue Xue Bao. 2021. PMID: 33849827 Free PMC article. Chinese.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous