Role of the serotonin transporter gene and family function in adolescent alcohol consumption - PubMed (original) (raw)
Role of the serotonin transporter gene and family function in adolescent alcohol consumption
Kent W Nilsson et al. Alcohol Clin Exp Res. 2005 Apr.
Abstract
Background: That the extent to which a particular individual will engage in problematic behaviors such as delinquency, violence, or drug abuse is determined by the way psychosocial, situational, and hereditary factors interact is widely accepted. However, only recently have researchers begun to investigate the interactions between specific genotypes and psychosocial factors in relation to behavior. The purpose of the present study was to investigate possible interactions between a polymorphism in the promoter region of the serotonin transporter (5-HTT) gene and family relations on adolescent alcohol consumption.
Methods: A cross-sectional study with a randomized sample from a total population of 16- and 19-year-old adolescents from a Swedish county was conducted. Eighty-one male and 119 female adolescents, who volunteered to participate after having answered a questionnaire, were randomly selected from quartiles of volunteers representing various degrees of psychosocial risk behavior.
Results: 5-HTT genotype (p=0.029) and family relations (p=0.022) predicted alcohol consumption independently as well as through an interaction with one another (p=0.05). The model explained 11% of the variance in alcohol consumption. In a binary logistic model, we found that adolescents with the LS variant of the 5-HTT gene and with family relations being "neutral" or "bad" had a 12- to 14-fold increased risk for high intoxication frequency.
Conclusions: In sum, our results show that a functional polymorphism of the 5-HTT genotype, family relations, and interactions between these variables predict adolescent alcohol consumption in a randomized sample of adolescents.
Similar articles
- Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.
Barr CS, Newman TK, Lindell S, Shannon C, Champoux M, Lesch KP, Suomi SJ, Goldman D, Higley JD. Barr CS, et al. Arch Gen Psychiatry. 2004 Nov;61(11):1146-52. doi: 10.1001/archpsyc.61.11.1146. Arch Gen Psychiatry. 2004. PMID: 15520362 - Association between 5-HTTLPR genotypes and persisting patterns of anxiety and alcohol use: results from a 10-year longitudinal study of adolescent mental health.
Olsson CA, Byrnes GB, Lotfi-Miri M, Collins V, Williamson R, Patton C, Anney RJ. Olsson CA, et al. Mol Psychiatry. 2005 Sep;10(9):868-76. doi: 10.1038/sj.mp.4001677. Mol Psychiatry. 2005. PMID: 15852063 - Serotonin transporter promoter polymorphism and monoamine oxidase type A VNTR allelic variants together influence alcohol binge drinking risk in young women.
Herman AI, Kaiss KM, Ma R, Philbeck JW, Hasan A, Dasti H, DePetrillo PB. Herman AI, et al. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):74-8. doi: 10.1002/ajmg.b.30135. Am J Med Genet B Neuropsychiatr Genet. 2005. PMID: 15635592 - The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments.
Serretti A, Benedetti F, Zanardi R, Smeraldi E. Serretti A, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):1074-84. doi: 10.1016/j.pnpbp.2005.03.013. Prog Neuropsychopharmacol Biol Psychiatry. 2005. PMID: 15939518 Review.
Cited by
- 5-HTTLPR status moderates the effect of early adolescent substance use on risky sexual behavior.
Kogan SM, Beach SR, Philibert RA, Brody GH, Chen YF, Lei MK. Kogan SM, et al. Health Psychol. 2010 Sep;29(5):471-6. doi: 10.1037/a0020594. Health Psychol. 2010. PMID: 20836601 Free PMC article. - Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study.
Cerniglia L, Cimino S, Marzilli E, Pascale E, Tambelli R. Cerniglia L, et al. JMIR Ment Health. 2020 Dec 24;7(12):e17341. doi: 10.2196/17341. JMIR Ment Health. 2020. PMID: 33361057 Free PMC article. - Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.
Williams PT. Williams PT. Behav Genet. 2020 Sep;50(5):332-345. doi: 10.1007/s10519-020-10005-z. Epub 2020 Jul 13. Behav Genet. 2020. PMID: 32661760 Free PMC article. - The role of brain serotonin signaling in excessive alcohol consumption and withdrawal: A call for more research in females.
Castle ME, Flanigan ME. Castle ME, et al. Neurobiol Stress. 2024 Feb 20;30:100618. doi: 10.1016/j.ynstr.2024.100618. eCollection 2024 May. Neurobiol Stress. 2024. PMID: 38433994 Free PMC article. - Interaction Between the 5-Hydroxytryptamine Transporter-Linked Polymorphic Region (5-HTTLPR) and Negative Life Events in Adolescent Heavy Drinking.
Kim J, Zaso MJ, Desalu JM, Park A. Kim J, et al. J Stud Alcohol Drugs. 2020 Sep;81(5):566-574. doi: 10.15288/jsad.2020.81.566. J Stud Alcohol Drugs. 2020. PMID: 33028469 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials