Wanted, an Anthrax vaccine: Dead or Alive? - PubMed (original) (raw)
Wanted, an Anthrax vaccine: Dead or Alive?
Kendall A Smith. Med Immunol. 2005.
Abstract
It has been more than 100 years since the realization that microbes are capable of causing disease. In that time, we have learned a great deal as to how each organism has adapted to the immune system so as to avoid elimination. As well, we have also learned an immense amount since Louis Pasteur first proposed that the solution to infectious diseases was to culture the microbes and attenuate their virulence, so as to use them as vaccines. From the optimism and promise of the 19th century and immunization as the ultimate answer to the invasion by the microbial world, to the scientific realities of the 21st century, it is of interest to retrace the steps of the earliest microbiologists cum immunologists, to realize how far we've come, as well as how far we yet have to go. This editorial focuses on the history of anthrax as a microbial disease, and the earliest efforts at producing a vaccine for its prevention.
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References
- Pasteur L, Chamberland. Roux De l'attenuation des virus et de leur retore a la virulence. Comptes Rendus des Seances de L'Academie des Sciences. 1881;92:430–435.
- Pasteur L. Sur les maladies virulentes, et en particulier sur la maladie appelee vulgairement cholera des poules. Comptes Rendus Hebdomadaires des Seances de l' Academie des Sciences. 1880;90:249–248.
- Koch R. Die aetiologie der milzbrand-krankheit, begrundet auf die entwicklungsgeschichte des bacillus antracis. Beitrage zur Biologie der Pflanzen. 1876;2:277–310.
- Metchnikoff E. The Founders of Modern Medicine: Pasteur, Koch, Lister. Freeport, NY, Books for Libraries Press; 1939.
- Metchnikoff E. Immunity in Infective Diseases. Cambridge, UK, Cambridge University Press; 1905. p. 576.
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