Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway? - PubMed (original) (raw)
Review
doi: 10.1038/nri1600.
Affiliations
- PMID: 15841100
- DOI: 10.1038/nri1600
Review
Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
Gérard Eberl. Nat Rev Immunol. 2005 May.
Abstract
The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.
Similar articles
- Dendritic cells from Peyer's patches and mesenteric lymph nodes differ from spleen dendritic cells in their response to commensal gut bacteria.
Fink LN, Frøkiaer H. Fink LN, et al. Scand J Immunol. 2008 Sep;68(3):270-9. doi: 10.1111/j.1365-3083.2008.02136.x. Epub 2008 Jun 19. Scand J Immunol. 2008. PMID: 18565117 - NALT- versus Peyer's-patch-mediated mucosal immunity.
Kiyono H, Fukuyama S. Kiyono H, et al. Nat Rev Immunol. 2004 Sep;4(9):699-710. doi: 10.1038/nri1439. Nat Rev Immunol. 2004. PMID: 15343369 Free PMC article. Review. - Anatomical basis of tolerance and immunity to intestinal antigens.
Mowat AM. Mowat AM. Nat Rev Immunol. 2003 Apr;3(4):331-41. doi: 10.1038/nri1057. Nat Rev Immunol. 2003. PMID: 12669023 Review. - Effects of early environment on mucosal immunologic homeostasis, subsequent immune responses and disease outcome.
Ogra PL, Welliver RC Sr. Ogra PL, et al. Nestle Nutr Workshop Ser Pediatr Program. 2008;61:145-81. doi: 10.1159/000113492. Nestle Nutr Workshop Ser Pediatr Program. 2008. PMID: 18196951 Review. - Lymphoid tissue inducer cells in intestinal immunity.
Ivanov II, Diehl GE, Littman DR. Ivanov II, et al. Curr Top Microbiol Immunol. 2006;308:59-82. doi: 10.1007/3-540-30657-9_3. Curr Top Microbiol Immunol. 2006. PMID: 16922086 Review.
Cited by
- Elucidation of the Effects of a Current X-SCID Therapy on Intestinal Lymphoid Organogenesis Using an In Vivo Animal Model.
Nochi T, Suzuki S, Ito S, Morita S, Furukawa M, Fuchimoto D, Sasahara Y, Usami K, Niimi K, Itano O, Kitago M, Matsuda S, Matsuo A, Suyama Y, Sakai Y, Wu G, Bazer FW, Watanabe K, Onishi A, Aso H. Nochi T, et al. Cell Mol Gastroenterol Hepatol. 2020;10(1):83-100. doi: 10.1016/j.jcmgh.2020.01.011. Epub 2020 Feb 1. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32017983 Free PMC article. - The thymus chapter in the life of gut-specific intra epithelial lymphocytes.
Cheroutre H, Lambolez F. Cheroutre H, et al. Curr Opin Immunol. 2008 Apr;20(2):185-91. doi: 10.1016/j.coi.2008.03.009. Epub 2008 May 2. Curr Opin Immunol. 2008. PMID: 18456487 Free PMC article. Review. - Keystones in lymph node development.
Blum KS, Pabst R. Blum KS, et al. J Anat. 2006 Nov;209(5):585-95. doi: 10.1111/j.1469-7580.2006.00650.x. J Anat. 2006. PMID: 17062017 Free PMC article. Review. - Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells.
Sanos SL, Vonarbourg C, Mortha A, Diefenbach A. Sanos SL, et al. Immunology. 2011 Apr;132(4):453-65. doi: 10.1111/j.1365-2567.2011.03410.x. Immunology. 2011. PMID: 21391996 Free PMC article. Review. - Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine.
Knoop KA, Butler BR, Kumar N, Newberry RD, Williams IR. Knoop KA, et al. Am J Pathol. 2011 Oct;179(4):1861-71. doi: 10.1016/j.ajpath.2011.06.004. Epub 2011 Aug 18. Am J Pathol. 2011. PMID: 21854748 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources