A cellular microRNA mediates antiviral defense in human cells - PubMed (original) (raw)
. 2005 Apr 22;308(5721):557-60.
doi: 10.1126/science.1108784.
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- PMID: 15845854
- DOI: 10.1126/science.1108784
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A cellular microRNA mediates antiviral defense in human cells
Charles-Henri Lecellier et al. Science. 2005.
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Abstract
In eukaryotes, 21- to 24-nucleotide-long RNAs engage in sequence-specific interactions that inhibit gene expression by RNA silencing. This process has regulatory roles involving microRNAs and, in plants and insects, it also forms the basis of a defense mechanism directed by small interfering RNAs that derive from replicative or integrated viral genomes. We show that a cellular microRNA effectively restricts the accumulation of the retrovirus primate foamy virus type 1 (PFV-1) in human cells. PFV-1 also encodes a protein, Tas, that suppresses microRNA-directed functions in mammalian cells and displays cross-kingdom antisilencing activities. Therefore, through fortuitous recognition of foreign nucleic acids, cellular microRNAs have direct antiviral effects in addition to their regulatory functions.
Comment in
- Molecular biology. Human RNA slows down a primate retrovirus.
Couzin J. Couzin J. Science. 2005 Apr 22;308(5721):480-1. doi: 10.1126/science.308.5721.480a. Science. 2005. PMID: 15845813 No abstract available.
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