T/B lineage choice occurs prior to intrathymic Notch signaling - PubMed (original) (raw)
. 2005 Aug 1;106(3):886-92.
doi: 10.1182/blood-2004-12-4881. Epub 2005 Apr 21.
Affiliations
- PMID: 15845899
- DOI: 10.1182/blood-2004-12-4881
Free article
T/B lineage choice occurs prior to intrathymic Notch signaling
Benjamin C Harman et al. Blood. 2005.
Free article
Abstract
Commitment of hemopoietic progenitors to the T-cell lineage is a crucial requirement for T-cell development, yet the timing and developmental cues regulating this process remain controversial. Here we have devised a technique to analyze the T-cell/B-cell lineage potential of precursors that have been recruited to the fetal mouse thymus but which have yet to contact the thymic epithelial microenvironment. We show that lymphoid progenitors arriving at the thymus are not bipotent T/B precursors, and provide evidence that intrathymic Notch signaling is not the mechanism determining T/B lineage choice in migrant precursors. Rather, we provide evidence that Notch signaling influences T/B lineage choice in lymphoid precursors through interactions with defined stromal components within the fetal liver. Collectively, our data redefine our understanding of the role and timing of Notch signaling in relation to lineage choices in lymphoid precursors.
Similar articles
- Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors.
Harman BC, Jenkinson EJ, Anderson G. Harman BC, et al. J Immunol. 2003 Feb 1;170(3):1299-303. doi: 10.4049/jimmunol.170.3.1299. J Immunol. 2003. PMID: 12538689 - Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment.
Heinzel K, Benz C, Martins VC, Haidl ID, Bleul CC. Heinzel K, et al. J Immunol. 2007 Jan 15;178(2):858-68. doi: 10.4049/jimmunol.178.2.858. J Immunol. 2007. PMID: 17202347 - Microenvironmental regulation of Notch signalling in T cell development.
Harman BC, Jenkinson EJ, Anderson G. Harman BC, et al. Semin Immunol. 2003 Apr;15(2):91-7. doi: 10.1016/s1044-5323(03)00005-8. Semin Immunol. 2003. PMID: 12681945 Review. - Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2.
Koga S, Hozumi K, Hirano KI, Yazawa M, Terooatea T, Minoda A, Nagasawa T, Koyasu S, Moro K. Koga S, et al. J Exp Med. 2018 Jun 4;215(6):1609-1626. doi: 10.1084/jem.20172310. Epub 2018 May 4. J Exp Med. 2018. PMID: 29728440 Free PMC article. - The thymus and T-cell commitment: the right niche for Notch?
Jenkinson EJ, Jenkinson WE, Rossi SW, Anderson G. Jenkinson EJ, et al. Nat Rev Immunol. 2006 Jul;6(7):551-5. doi: 10.1038/nri1883. Nat Rev Immunol. 2006. PMID: 16799474 Review.
Cited by
- T cell lineage commitment: identity and renunciation.
Rothenberg EV. Rothenberg EV. J Immunol. 2011 Jun 15;186(12):6649-55. doi: 10.4049/jimmunol.1003703. J Immunol. 2011. PMID: 21646301 Free PMC article. Review. - Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.
Maillard I, Schwarz BA, Sambandam A, Fang T, Shestova O, Xu L, Bhandoola A, Pear WS. Maillard I, et al. Blood. 2006 May 1;107(9):3511-9. doi: 10.1182/blood-2005-08-3454. Epub 2006 Jan 5. Blood. 2006. PMID: 16397133 Free PMC article. - Delta-like 4 is indispensable in thymic environment specific for T cell development.
Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Holländer GA, Shima DT, Habu S. Hozumi K, et al. J Exp Med. 2008 Oct 27;205(11):2507-13. doi: 10.1084/jem.20080134. Epub 2008 Sep 29. J Exp Med. 2008. PMID: 18824583 Free PMC article. - Transcriptional control of early T and B cell developmental choices.
Rothenberg EV. Rothenberg EV. Annu Rev Immunol. 2014;32:283-321. doi: 10.1146/annurev-immunol-032712-100024. Epub 2014 Jan 22. Annu Rev Immunol. 2014. PMID: 24471430 Free PMC article. Review. - Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors.
Luis TC, Luc S, Mizukami T, Boukarabila H, Thongjuea S, Woll PS, Azzoni E, Giustacchini A, Lutteropp M, Bouriez-Jones T, Vaidya H, Mead AJ, Atkinson D, Böiers C, Carrelha J, Macaulay IC, Patient R, Geissmann F, Nerlov C, Sandberg R, de Bruijn MFTR, Blackburn CC, Godin I, Jacobsen SEW. Luis TC, et al. Nat Immunol. 2016 Dec;17(12):1424-1435. doi: 10.1038/ni.3576. Epub 2016 Oct 3. Nat Immunol. 2016. PMID: 27695000 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases