Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy - PubMed (original) (raw)
Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy
Mitchell S Anscher et al. Int J Radiat Oncol Biol Phys. 2005.
Abstract
The ability to optimize treatments for cancer on the basis of relative risks for normal tissue injury has important implications in oncology, because higher doses of radiation might, in some diseases, improve both local control and survival. To achieve this goal, a thorough understanding of the molecular mechanisms responsible for radiation-induced toxicity will be essential. Recent research has demonstrated that ionizing radiation triggers a series of genetic and molecular events, which might lead to chronic persistent alterations in the microenvironment and an aberrant wound-healing response. Disrupted epithelial-stromal cell communication might also be important. With the application of a better understanding of fundamental biology to clinical practice, new approaches to treating and preventing normal tissue injury can focus on correcting these disturbed molecular processes.
Comment in
- Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy: In regard to Anscher et al. (Int J Radiat Oncol Biol Phys 2005;62:255-259).
Sminia P, Mayer R, van der Kleij A, Feldmeier J. Sminia P, et al. Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):649-50; author reply 650. doi: 10.1016/j.ijrobp.2005.05.058. Int J Radiat Oncol Biol Phys. 2005. PMID: 16168862 No abstract available.
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