TLR11 activation of dendritic cells by a protozoan profilin-like protein - PubMed (original) (raw)
. 2005 Jun 10;308(5728):1626-9.
doi: 10.1126/science.1109893. Epub 2005 Apr 28.
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- PMID: 15860593
- DOI: 10.1126/science.1109893
Free article
TLR11 activation of dendritic cells by a protozoan profilin-like protein
Felix Yarovinsky et al. Science. 2005.
Free article
Abstract
Mammalian Toll-like receptors (TLRs) play an important role in the innate recognition of pathogens by dendritic cells (DCs). Although TLRs are clearly involved in the detection of bacteria and viruses, relatively little is known about their function in the innate response to eukaryotic microorganisms. Here we identify a profilin-like molecule from the protozoan parasite Toxoplasma gondii that generates a potent interleukin-12 (IL-12) response in murine DCs that is dependent on myeloid differentiation factor 88. T. gondii profilin activates DCs through TLR11 and is the first chemically defined ligand for this TLR. Moreover, TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection, thereby establishing a role for the receptor in host recognition of protozoan pathogens.
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- 1R01AI045806-01A1/AI/NIAID NIH HHS/United States
- AI05093/AI/NIAID NIH HHS/United States
- R01-AI59440/AI/NIAID NIH HHS/United States
- R01-GM38765/GM/NIGMS NIH HHS/United States
- Intramural NIH HHS/United States
- Wellcome Trust/United Kingdom
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