FGF23 and disorders of phosphate homeostasis - PubMed (original) (raw)
Review
FGF23 and disorders of phosphate homeostasis
Xijie Yu et al. Cytokine Growth Factor Rev. 2005 Apr.
Abstract
It is well known that fibroblast growth factor (FGF) family members are associated with embryonic development and are critical for basic metabolic functions. This review will focus upon fibroblast growth factor-23 (FGF23) and its roles in disorders associated with phosphate handling. The discovery that mutations in FGF23 were responsible for the isolated renal phosphate wasting disorder autosomal dominant hypophosphatemic rickets (ADHR) has ascribed novel functions to the FGF family. FGF23 circulates in the bloodstream, and animal models demonstrate that FGF23 controls phosphate and Vitamin D homeostasis through the regulation of specific renal proteins. The ADHR mutations in FGF23 produce a protein species less susceptible to proteolytic processing. X-linked hypophosphatemic rickets (XLH), tumor-induced osteomalacia (TIO), and fibrous dysplasia of bone (FD) are disorders involving phosphate homeostasis that share phenotypes with ADHR, indicating that FGF23 may be a common denominator for the pathophysiology of these syndromes. Our understanding of FGF23 will help to develop novel therapies for phosphate wasting disorders, as well as for disorders of increased serum phosphate, such as tumoral calcinosis, a rare disorder, and renal failure, a common disorder.
Similar articles
- FGF23, PHEX, and MEPE regulation of phosphate homeostasis and skeletal mineralization.
Quarles LD. Quarles LD. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E1-9. doi: 10.1152/ajpendo.00016.2003. Am J Physiol Endocrinol Metab. 2003. PMID: 12791601 Review. - Fibroblast growth factor 23 and its receptors.
Yu X, White KE. Yu X, et al. Ther Apher Dial. 2005 Aug;9(4):308-12. doi: 10.1111/j.1744-9987.2005.00287.x. Ther Apher Dial. 2005. PMID: 16076372 Review. - Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23.
ADHR Consortium. ADHR Consortium. Nat Genet. 2000 Nov;26(3):345-8. doi: 10.1038/81664. Nat Genet. 2000. PMID: 11062477 - Emerging role of a phosphatonin in mineral homeostasis and its derangements.
Bielesz B. Bielesz B. Eur J Clin Invest. 2006 Aug;36 Suppl 2:34-42. doi: 10.1111/j.1365-2362.2006.01659.x. Eur J Clin Invest. 2006. PMID: 16884396 Review. - Fibrous dysplasia, phosphate wasting and fibroblast growth factor 23.
Imel EA, Econs MJ. Imel EA, et al. Pediatr Endocrinol Rev. 2007 Aug;4 Suppl 4:434-9. Pediatr Endocrinol Rev. 2007. PMID: 17982392 Review.
Cited by
- Characteristics of oral health of patients with X-linked hypophosphatemia: case reports and literature review.
Arhar A, Pavlič A, Hočevar L. Arhar A, et al. BDJ Open. 2024 May 31;10(1):42. doi: 10.1038/s41405-024-00223-6. BDJ Open. 2024. PMID: 38821917 Free PMC article. Review. - Fibroblast Growth Factor 23 Bone Regulation and Downstream Hormonal Activity.
Clinkenbeard E. Clinkenbeard E. Calcif Tissue Int. 2023 Jul;113(1):4-20. doi: 10.1007/s00223-023-01092-1. Epub 2023 Jun 12. Calcif Tissue Int. 2023. PMID: 37306735 Review. - Effect of vitamin D supplementation on circulating fibroblast growth factor-23 concentration in adults with prediabetes.
Ceglia L, Pittas AG, Dawson-Hughes B. Ceglia L, et al. Aging Clin Exp Res. 2023 Mar;35(3):525-530. doi: 10.1007/s40520-022-02338-y. Epub 2023 Jan 11. Aging Clin Exp Res. 2023. PMID: 36631721 - Fibroblast Growth Factors and Cellular Communication Network Factors: Intimate Interplay by the Founding Members in Cartilage.
Kubota S, Aoyama E, Takigawa M, Nishida T. Kubota S, et al. Int J Mol Sci. 2022 Aug 2;23(15):8592. doi: 10.3390/ijms23158592. Int J Mol Sci. 2022. PMID: 35955724 Free PMC article. Review. - A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo.
Lee SM, Carlson AH, Onal M, Benkusky NA, Meyer MB, Pike JW. Lee SM, et al. Endocrinology. 2019 Dec 1;160(12):2877-2891. doi: 10.1210/en.2019-00622. Endocrinology. 2019. PMID: 31599948 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources