Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57 - PubMed (original) (raw)
Comparative Study
. 2005 May 15;174(10):6088-94.
doi: 10.4049/jimmunol.174.10.6088.
Affiliations
- PMID: 15879103
- DOI: 10.4049/jimmunol.174.10.6088
Comparative Study
Expression of killer cell lectin-like receptor G1 on antigen-specific human CD8+ T lymphocytes during active, latent, and resolved infection and its relation with CD57
Chris C Ibegbu et al. J Immunol. 2005.
Erratum in
- J Immunol. 2006 Jun 15;176(12):7787
Abstract
Killer cell lectin-like receptor G1 (KLRG1) is one of several inhibitory killer cell lectin-like receptors expressed by NK cells and T lymphocytes, mainly CD8(+) effector/memory cells that can secrete cytokines but have poor proliferative capacity. Using multiparameter flow cytometry, we studied KLRG1 expression on CD8(+) T cells specific for epitopes of CMV, EBV, influenza, and HIV. Over 92% of CD8(+) cells specific for CMV or EBV expressed KLRG1 during the latent stage of these chronic infections. CD8(+) T cell cells specific for HIV epitopes were mostly (72-89%) KLRG1(+), even though not quite at the level of predominance noted with CMV or EBV. Lower frequency of KLRG1 expression was observed among CD8(+) cells specific for influenza (40-73%), a resolved infection without a latent stage. We further observed that CD8(+) cells expressing CD57, a marker of replicative senescence, also expressed KLRG1; however, a population of CD57(-)KLRG1(+) cells was also identified. This population may represent a "memory" phenotype, because they also expressed CD27, CD28, CCR7, and CD127. In contrast, CD57(+)KLRG1(+) cells did not express CD27, CD28, and CCR7, and expressed CD127 at a much lower frequency, indicating that they represent effector cells that are truly terminally differentiated. The combination of KLRG1 and CD57 expression might thus aid in refining functional characterization of CD8(+) T cell subsets.
Similar articles
- Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control.
Hoji A, Popescu ID, Pipeling MR, Shah PD, Winters SA, McDyer JF. Hoji A, et al. J Immunol. 2019 Oct 15;203(8):2063-2075. doi: 10.4049/jimmunol.1900399. Epub 2019 Sep 25. J Immunol. 2019. PMID: 31554693 Free PMC article. - Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging.
Lee SA, Sinclair E, Hatano H, Hsue PY, Epling L, Hecht FM, Bangsberg DR, Martin JN, McCune JM, Deeks SG, Hunt PW. Lee SA, et al. PLoS One. 2014 Feb 27;9(2):e89444. doi: 10.1371/journal.pone.0089444. eCollection 2014. PLoS One. 2014. PMID: 24586783 Free PMC article. - NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection.
Bigley AB, Lowder TW, Spielmann G, Rector JL, Pircher H, Woods JA, Simpson RJ. Bigley AB, et al. Brain Behav Immun. 2012 Jan;26(1):177-86. doi: 10.1016/j.bbi.2011.09.004. Epub 2011 Sep 10. Brain Behav Immun. 2012. PMID: 21933704 - CD57 in human natural killer cells and T-lymphocytes.
Kared H, Martelli S, Ng TP, Pender SL, Larbi A. Kared H, et al. Cancer Immunol Immunother. 2016 Apr;65(4):441-52. doi: 10.1007/s00262-016-1803-z. Epub 2016 Feb 5. Cancer Immunol Immunother. 2016. PMID: 26850637 Free PMC article. Review. - KLRG1--more than a marker for T cell senescence.
Henson SM, Akbar AN. Henson SM, et al. Age (Dordr). 2009 Dec;31(4):285-91. doi: 10.1007/s11357-009-9100-9. Age (Dordr). 2009. PMID: 19479342 Free PMC article. Review.
Cited by
- Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC.
Naigeon M, Roulleaux Dugage M, Danlos FX, Boselli L, Jouniaux JM, de Oliveira C, Ferrara R, Duchemann B, Berthot C, Girard L, Flippot R, Albiges L, Farhane S, Saulnier P, Lacroix L, Griscelli F, Roman G, Hulett T, Marabelle A, Cassard L, Besse B, Chaput N. Naigeon M, et al. Sci Adv. 2023 Nov 10;9(45):eadh0708. doi: 10.1126/sciadv.adh0708. Epub 2023 Nov 8. Sci Adv. 2023. PMID: 37939189 Free PMC article. - The architectural design of CD8+ T cell responses in acute and chronic infection: Parallel structures with divergent fates.
Chung HK, McDonald B, Kaech SM. Chung HK, et al. J Exp Med. 2021 Apr 5;218(4):e20201730. doi: 10.1084/jem.20201730. J Exp Med. 2021. PMID: 33755719 Free PMC article. Review. - Convergent clonal selection of donor- and recipient-derived CMV-specific T cells in hematopoietic stem cell transplant patients.
Erickson JR, Stevens-Ayers T, Mair F, Edmison B, Boeckh M, Bradley P, Prlic M. Erickson JR, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2117031119. doi: 10.1073/pnas.2117031119. Proc Natl Acad Sci U S A. 2022. PMID: 35105810 Free PMC article. - Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes.
Luce S, Lemonnier F, Briand JP, Coste J, Lahlou N, Muller S, Larger E, Rocha B, Mallone R, Boitard C. Luce S, et al. Diabetes. 2011 Dec;60(12):3289-99. doi: 10.2337/db11-0270. Epub 2011 Oct 13. Diabetes. 2011. PMID: 21998398 Free PMC article. - IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells.
Cheng G, Yuan X, Tsai MS, Podack ER, Yu A, Malek TR. Cheng G, et al. J Immunol. 2012 Aug 15;189(4):1780-91. doi: 10.4049/jimmunol.1103768. Epub 2012 Jul 11. J Immunol. 2012. PMID: 22786769 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials