Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1 - PubMed (original) (raw)

doi: 10.1038/ni1203. Epub 2005 May 8.

Affiliations

• PMID: 15880112
• DOI: 10.1038/ni1203

Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

Fabio M V Rossi et al. Nat Immunol. 2005 Jun.

Abstract

The molecular mechanisms that direct the migration of early T lymphocyte progenitors to the thymus are unknown. We show here that P-selectin is expressed by thymic endothelium and that lymphoid progenitors in bone marrow and thymus bind P-selectin. Parabiosis, competitive thymus reconstitution and short-term homing assays indicated that P-selectin and its ligand PSGL-1 are functionally important components of the thymic homing process. Accordingly, thymi of mice lacking PSGL-1 contained fewer early thymic progenitors and had increased empty niches for prothymocytes compared with wild-type mice. Furthermore, the number of resident thymic progenitors controls thymic expression of P-selectin, suggesting that regulation of P-selectin expression by a thymic 'niche occupancy sensor' may be used to direct progenitor access.

PubMed Disclaimer

Similar articles

• P-selectin glycoprotein ligand-1 mediates L-selectin-independent leukocyte rolling in high endothelial venules of peripheral lymph nodes.
  Harakawa N, Shigeta A, Wato M, Merrill-Skoloff G, Furie BC, Furie B, Okazaki T, Domae N, Miyasaka M, Hirata T. Harakawa N, et al. Int Immunol. 2007 Mar;19(3):321-9. doi: 10.1093/intimm/dxl149. Epub 2007 Jan 30. Int Immunol. 2007. PMID: 17267415
• Expression of functional P-selectin glycoprotein ligand 1 on hematopoietic progenitors is developmentally regulated.
  Sultana DA, Zhang SL, Todd SP, Bhandoola A. Sultana DA, et al. J Immunol. 2012 May 1;188(9):4385-93. doi: 10.4049/jimmunol.1101116. Epub 2012 Mar 28. J Immunol. 2012. PMID: 22461691 Free PMC article.
• Lack of functional P-selectin ligand exacerbates Salmonella serovar typhimurium infection.
  Kum WW, Lee S, Grassl GA, Bidshahri R, Hsu K, Ziltener HJ, Finlay BB. Kum WW, et al. J Immunol. 2009 May 15;182(10):6550-61. doi: 10.4049/jimmunol.0802536. J Immunol. 2009. PMID: 19414810
• PSGL-1 function in immunity and steady state homeostasis.
  Carlow DA, Gossens K, Naus S, Veerman KM, Seo W, Ziltener HJ. Carlow DA, et al. Immunol Rev. 2009 Jul;230(1):75-96. doi: 10.1111/j.1600-065X.2009.00797.x. Immunol Rev. 2009. PMID: 19594630 Review.
• Cyclical mobilization and gated importation of thymocyte progenitors in the adult mouse: evidence for a thymus-bone marrow feedback loop.
  Goldschneider I. Goldschneider I. Immunol Rev. 2006 Feb;209:58-75. doi: 10.1111/j.0105-2896.2006.00354.x. Immunol Rev. 2006. PMID: 16448534 Review.

Cited by

• Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus.
  Lucas B, James KD, Cosway EJ, Parnell SM, Tumanov AV, Ware CF, Jenkinson WE, Anderson G. Lucas B, et al. J Immunol. 2016 Oct 1;197(7):2665-72. doi: 10.4049/jimmunol.1601189. Epub 2016 Aug 22. J Immunol. 2016. PMID: 27549174 Free PMC article.
• Intravital two-photon microscopy of the native mouse thymus.
  Seyedhassantehrani N, Burns CS, Verrinder R, Okafor V, Abbasizadeh N, Spencer JA. Seyedhassantehrani N, et al. PLoS One. 2024 Aug 1;19(8):e0307962. doi: 10.1371/journal.pone.0307962. eCollection 2024. PLoS One. 2024. PMID: 39088574 Free PMC article.
• Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cells.
  Banerjee ER, Latchman YE, Jiang Y, Priestley GV, Papayannopoulou T. Banerjee ER, et al. Exp Hematol. 2008 Aug;36(8):1004-13. doi: 10.1016/j.exphem.2008.03.008. Epub 2008 May 12. Exp Hematol. 2008. PMID: 18468770 Free PMC article.
• Differential regulation of human and murine P-selectin expression and function in vivo.
  Liu Z, Miner JJ, Yago T, Yao L, Lupu F, Xia L, McEver RP. Liu Z, et al. J Exp Med. 2010 Dec 20;207(13):2975-87. doi: 10.1084/jem.20101545. Epub 2010 Dec 13. J Exp Med. 2010. PMID: 21149548 Free PMC article.
• The long road to the thymus: the generation, mobilization, and circulation of T-cell progenitors in mouse and man.
  Zlotoff DA, Schwarz BA, Bhandoola A. Zlotoff DA, et al. Semin Immunopathol. 2008 Dec;30(4):371-82. doi: 10.1007/s00281-008-0133-4. Epub 2008 Oct 17. Semin Immunopathol. 2008. PMID: 18925398 Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • H1 Connect
  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • Mouse Genome Informatics (MGI)