The intracellular fate of Salmonella depends on the recruitment of kinesin - PubMed (original) (raw)
. 2005 May 20;308(5725):1174-8.
doi: 10.1126/science.1110225.
Affiliations
- PMID: 15905402
- DOI: 10.1126/science.1110225
The intracellular fate of Salmonella depends on the recruitment of kinesin
Emmanuel Boucrot et al. Science. 2005.
Abstract
Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. The success of this pathogen depends on its capacity to proliferate within host cells in a membrane-bound compartment. We found that the Salmonella-containing vacuole recruited the plus-end-directed motor kinesin. Bacterial effector proteins translocated into the host cell by a type III secretion system antagonistically regulated this event. Among these effectors, SifA targeted SKIP, a host protein that down-regulated the recruitment of kinesin on the bacterial vacuole and, in turn, controlled vacuolar membrane dynamics.
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