Signaling of the tissue factor coagulation pathway in angiogenesis and cancer - PubMed (original) (raw)

Review

Signaling of the tissue factor coagulation pathway in angiogenesis and cancer

Mattias Belting et al. Arterioscler Thromb Vasc Biol. 2005 Aug.

Abstract

Activation of coagulation precedes or coincides with angiogenesis in wound healing and postischemic tissue regeneration. Advanced cancer is associated with a hypercoagulable state, and tissue factor expression by cancer cells has received widespread attention because of its significant contribution to the pathogenesis of cancer progression and metastasis. Our recent work demonstrates that tissue factor-mediated cellular signaling is relevant to cancer angiogenesis. Here we review the molecular mechanisms of tissue factor pathways in angiogenesis and tumorigenesis with emphasis on the intriguing role for tissue factor cytoplasmic domain signaling.

PubMed Disclaimer

Similar articles

• Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.
  Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W. Belting M, et al. Nat Med. 2004 May;10(5):502-9. doi: 10.1038/nm1037. Epub 2004 Apr 18. Nat Med. 2004. PMID: 15098027
• Tissue factor--a receptor involved in the control of cellular properties, including angiogenesis.
  Chen J, Bierhaus A, Schiekofer S, Andrassy M, Chen B, Stern DM, Nawroth PP. Chen J, et al. Thromb Haemost. 2001 Jul;86(1):334-45. Thromb Haemost. 2001. PMID: 11487022 Review.
• Genetic determinants of cancer coagulopathy, angiogenesis and disease progression.
  Rak J, Klement P, Yu J. Rak J, et al. Vnitr Lek. 2006 Mar;52 Suppl 1:135-8. Vnitr Lek. 2006. PMID: 16637463 Review.
• Tissue factor signal transduction in angiogenesis.
  Versteeg HH, Peppelenbosch MP, Spek CA. Versteeg HH, et al. Carcinogenesis. 2003 Jun;24(6):1009-13. doi: 10.1093/carcin/bgg039. Epub 2003 Mar 28. Carcinogenesis. 2003. PMID: 12807741 Review.
• Tissue factor: biological function and clinical significance.
  Lwaleed BA. Lwaleed BA. Saudi Med J. 2002 Feb;23(2):135-43. Saudi Med J. 2002. PMID: 11938386 Review.

Cited by

• HIF-mediated endothelial response during cancer progression.
  Evans CE, Branco-Price C, Johnson RS. Evans CE, et al. Int J Hematol. 2012 May;95(5):471-7. doi: 10.1007/s12185-012-1072-3. Epub 2012 May 8. Int J Hematol. 2012. PMID: 22562456 Review.
• Role of tissue factor disulfides and lipid rafts in signaling.
  Pendurthi UR, Rao LV. Pendurthi UR, et al. Thromb Res. 2008;122 Suppl 1(Suppl 1):S14-8. doi: 10.1016/S0049-3848(08)70012-4. Thromb Res. 2008. PMID: 18691492 Free PMC article. Review.
• Endothelial cell control of thrombosis.
  Yau JW, Teoh H, Verma S. Yau JW, et al. BMC Cardiovasc Disord. 2015 Oct 19;15:130. doi: 10.1186/s12872-015-0124-z. BMC Cardiovasc Disord. 2015. PMID: 26481314 Free PMC article. Review.
• Anti-angiogenic effect of the total flavonoids in Scutellaria barbata D. Don.
  Dai ZJ, Lu WF, Gao J, Kang HF, Ma YG, Zhang SQ, Diao Y, Lin S, Wang XJ, Wu WY. Dai ZJ, et al. BMC Complement Altern Med. 2013 Jul 1;13:150. doi: 10.1186/1472-6882-13-150. BMC Complement Altern Med. 2013. PMID: 23815868 Free PMC article.
• Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo.
  Ramelli G, Fuertes S, Narayan S, Busso N, Acha-Orbea H, So A. Ramelli G, et al. Immunology. 2010 Jan;129(1):20-7. doi: 10.1111/j.1365-2567.2009.03144.x. Epub 2009 Jun 22. Immunology. 2010. PMID: 19845798 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database