Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression - PubMed (original) (raw)
. 2005 Sep 1;106(5):1694-702.
doi: 10.1182/blood-2005-02-0494. Epub 2005 May 26.
Séverine Rémy, Pierre Joseph Royer, Marcelo Hill, Séverine Tanguy-Royer, François-Xavier Hubert, Laurent Tesson, Régis Brion, Gaëlle Beriou, Marc Gregoire, Régis Josien, Maria Cristina Cuturi, Ignacio Anegon
Affiliations
- PMID: 15920011
- DOI: 10.1182/blood-2005-02-0494
Free article
Heme oxygenase-1 expression inhibits dendritic cell maturation and proinflammatory function but conserves IL-10 expression
Christine Chauveau et al. Blood. 2005.
Free article
Abstract
Heme oxygenase-1 (HO-1) is an intracellular enzyme that degrades heme and inhibits immune responses and inflammation in vivo. In most cell types, HO-1 is inducible by inflammatory stimuli and oxidative stress. Here we demonstrate that human monocyte-derived immature dendritic cells (iDCs) and several but not all freshly isolated rat splenic DC subsets and rat bone marrow-derived iDCs, spontaneously express HO-1. HO-1 expression drastically decreases during human and rat DC maturation induced in vitro. In human tissues, iDCs also express HO-1, whereas mature DCs do not. Induction of HO-1 expression with cobalt protoporphyrin (CoPP) in human and rat DCs inhibits lipopolysaccharide (LPS)-induced phenotypic maturation and secretion of proinflammatory cytokines, resulting in the inhibition of alloreactive T-cell proliferation. CoPP-treated DCs, however, retain the ability to produce the anti-inflammatory cytokine interleukin 10 (IL-10). Reactive oxygen species induced by LPS in DCs were inhibited by induction of HO-1. In conclusion, we identify, for the first time, the capacity of HO-1 to block maturation of DCs and to inhibit proinflammatory and allogeneic immune responses while preserving IL-10 production. This novel immune function for HO-1 may be of interest for the inhibition of immune responses in autoimmune diseases, transplantation, and other conditions involving activation of the immune system.
Similar articles
- Effective protective mechanisms of HO-1 in diabetic complications: a narrative review.
Zhang JJ, Ni P, Song Y, Gao MJ, Guo XY, Zhao BQ. Zhang JJ, et al. Cell Death Discov. 2024 Oct 10;10(1):433. doi: 10.1038/s41420-024-02205-x. Cell Death Discov. 2024. PMID: 39389941 Free PMC article. Review. - Heme oxygenase-1 inhibits T cell-dependent skin inflammation and differentiation and function of antigen-presenting cells.
Listopad J, Asadullah K, Sievers C, Ritter T, Meisel C, Sabat R, Döcke WD. Listopad J, et al. Exp Dermatol. 2007 Aug;16(8):661-70. doi: 10.1111/j.1600-0625.2007.00581.x. Exp Dermatol. 2007. PMID: 17620093 - Saucerneol D inhibits dendritic cell activation by inducing heme oxygenase-1, but not by directly inhibiting toll-like receptor 4 signaling.
Ryu HS, Lee HK, Kim JS, Kim YG, Pyo M, Yun J, Hwang BY, Hong JT, Kim Y, Han SB. Ryu HS, et al. J Ethnopharmacol. 2015 May 26;166:92-101. doi: 10.1016/j.jep.2015.03.020. Epub 2015 Mar 17. J Ethnopharmacol. 2015. PMID: 25792017 - Immune Regulation of Heme Oxygenase-1 in Allergic Airway Inflammation.
Xia Z, Zhong W. Xia Z, et al. Antioxidants (Basel). 2022 Feb 26;11(3):465. doi: 10.3390/antiox11030465. Antioxidants (Basel). 2022. PMID: 35326116 Free PMC article. Review.
Cited by
- Effective protective mechanisms of HO-1 in diabetic complications: a narrative review.
Zhang JJ, Ni P, Song Y, Gao MJ, Guo XY, Zhao BQ. Zhang JJ, et al. Cell Death Discov. 2024 Oct 10;10(1):433. doi: 10.1038/s41420-024-02205-x. Cell Death Discov. 2024. PMID: 39389941 Free PMC article. Review. - NRF2 Plays a Crucial Role in the Tolerogenic Effect of Ethyl Pyruvate on Dendritic Cells.
Stanisavljević S, Stegnjaić G, Jevtić B, Dimitrijević M, Miljković Đ, Lavrnja I, Nikolovski N. Stanisavljević S, et al. Int J Mol Sci. 2024 Jun 4;25(11):6195. doi: 10.3390/ijms25116195. Int J Mol Sci. 2024. PMID: 38892383 Free PMC article. - Antioxidant mechanisms of mesenchymal stem cells and their therapeutic potential in vitiligo.
Yang RL, Chen SY, Fu SP, Zhao DZ, Wan WH, Yang K, Lei W, Yang Y, Zhang Q, Zhang T. Yang RL, et al. Front Cell Dev Biol. 2023 Dec 21;11:1293101. doi: 10.3389/fcell.2023.1293101. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38178870 Free PMC article. Review. - Innate immune cellular therapeutics in transplantation.
Ott LC, Cuenca AG. Ott LC, et al. Front Transplant. 2023;2:1067512. doi: 10.3389/frtra.2023.1067512. Epub 2023 Mar 31. Front Transplant. 2023. PMID: 37994308 Free PMC article. - Veronica persica Ethanol Extract Ameliorates Dinitrochlorobenzene-Induced Atopic Dermatitis-like Skin Inflammation in Mice, Likely by Inducing Nrf2/HO-1 Signaling.
Shim KS, Park M, Yang WK, Lee H, Kim SH, Choo BK, Chae S, Kim HK, Kim T, Kim KM. Shim KS, et al. Antioxidants (Basel). 2023 Jun 13;12(6):1267. doi: 10.3390/antiox12061267. Antioxidants (Basel). 2023. PMID: 37371997 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources