Hemoglobin mediated nitrite activation of soluble guanylyl cyclase - PubMed (original) (raw)
Hemoglobin mediated nitrite activation of soluble guanylyl cyclase
Anne Jeffers et al. Comp Biochem Physiol A Mol Integr Physiol. 2005 Oct.
Abstract
Nitrite has long been known to be vasoactive when present at large concentrations but it was thought to be inactive under physiological conditions. Surprisingly, we have recently shown that supraphysiological and near physiological concentrations of nitrite cause vasodilation in the human circulation. These effects appeared to result from reduction of nitrite by deoxygenated hemoglobin. Thus, nitrite was proposed to play a role in hypoxic vasodilation. We now discuss these results in the context of nitrite reacting with hemoglobin and effecting vasodilation and present new data modeling the nitric oxide (NO) export from the red blood cell and measurements of soluble guanylate cyclase (sGC) activation. We conclude that NO generated within the interior of the red blood cell is not likely to be effectively exported directly as nitric oxide. Thus, an intermediate species must be formed by the nitrite/deoxyhemoglobin reaction that escapes the red cell and effects vasodilation.
Similar articles
- Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities.
Dalsgaard T, Simonsen U, Fago A. Dalsgaard T, et al. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3072-8. doi: 10.1152/ajpheart.01298.2006. Epub 2007 Feb 16. Am J Physiol Heart Circ Physiol. 2007. PMID: 17307993 - Human soluble guanylate cyclase as a nitric oxide sensor for NO-signalling reveals a novel function of nitrite reductase.
Pan J, Xu Q, Lin YW, Zhong F, Tan X. Pan J, et al. Chem Commun (Camb). 2013 Aug 28;49(67):7454-6. doi: 10.1039/c3cc43321h. Chem Commun (Camb). 2013. PMID: 23864033 - Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics.
Kim-Shapiro DB, Schechter AN, Gladwin MT. Kim-Shapiro DB, et al. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):697-705. doi: 10.1161/01.ATV.0000204350.44226.9a. Epub 2006 Jan 19. Arterioscler Thromb Vasc Biol. 2006. PMID: 16424350 Review. - Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation.
Totzeck M, Hendgen-Cotta UB, Luedike P, Berenbrink M, Klare JP, Steinhoff HJ, Semmler D, Shiva S, Williams D, Kipar A, Gladwin MT, Schrader J, Kelm M, Cossins AR, Rassaf T. Totzeck M, et al. Circulation. 2012 Jul 17;126(3):325-34. doi: 10.1161/CIRCULATIONAHA.111.087155. Epub 2012 Jun 9. Circulation. 2012. PMID: 22685116 Free PMC article. - Regulation of nitric oxide and soluble guanylyl cyclase.
Krumenacker JS, Hanafy KA, Murad F. Krumenacker JS, et al. Brain Res Bull. 2004 Feb 15;62(6):505-15. doi: 10.1016/S0361-9230(03)00102-3. Brain Res Bull. 2004. PMID: 15036565 Review.
Cited by
- Differences in oxygen-dependent nitric oxide metabolism by cytoglobin and myoglobin account for their differing functional roles.
Liu X, Tong J, Zweier JR, Follmer D, Hemann C, Ismail RS, Zweier JL. Liu X, et al. FEBS J. 2013 Aug;280(15):3621-31. doi: 10.1111/febs.12352. Epub 2013 Jun 24. FEBS J. 2013. PMID: 23710929 Free PMC article. - Nitrite and nitrate chemical biology and signalling.
DeMartino AW, Kim-Shapiro DB, Patel RP, Gladwin MT. DeMartino AW, et al. Br J Pharmacol. 2019 Jan;176(2):228-245. doi: 10.1111/bph.14484. Epub 2018 Oct 3. Br J Pharmacol. 2019. PMID: 30152056 Free PMC article. Review. - Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective.
Chen K, Pittman RN, Popel AS. Chen K, et al. Antioxid Redox Signal. 2008 Jul;10(7):1185-98. doi: 10.1089/ars.2007.1959. Antioxid Redox Signal. 2008. PMID: 18331202 Free PMC article. Review. - Nitric oxide production pathways in erythrocytes and plasma.
Chen K, Popel AS. Chen K, et al. Biorheology. 2009;46(2):107-19. doi: 10.3233/BIR-2009-0531. Biorheology. 2009. PMID: 19458414 Free PMC article. Review. - Endogenous Hemoprotein-Dependent Signaling Pathways of Nitric Oxide and Nitrite.
Dent MR, DeMartino AW, Tejero J, Gladwin MT. Dent MR, et al. Inorg Chem. 2021 Nov 1;60(21):15918-15940. doi: 10.1021/acs.inorgchem.1c01048. Epub 2021 Jul 27. Inorg Chem. 2021. PMID: 34313417 Free PMC article. Review.