Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR - PubMed (original) (raw)

Review

Overview on sugar metabolism and its control in Lactococcus lactis - the input from in vivo NMR

Ana Rute Neves et al. FEMS Microbiol Rev. 2005 Aug.

Free article

Abstract

The wide application of lactic acid bacteria in the production of fermented foods depends to a great extent on the unique features of sugar metabolism in these organisms. The relative metabolic simplicity and the availability of genetic tools made Lactococcus lactis the organism of choice to gain insight into metabolic and regulatory networks. In vivo nuclear magnetic resonance has proven a very useful technique to monitor non-invasively the dynamics of intracellular metabolite and co-factor pools following a glucose pulse. Examples of the application of this methodology to identify metabolic bottlenecks and regulatory sites are presented. The use of this information to direct metabolic engineering strategies is illustrated.

PubMed Disclaimer

Similar articles

• Metabolism of lactic acid bacteria studied by nuclear magnetic resonance.
  Ramos A, Neves AR, Santos H. Ramos A, et al. Antonie Van Leeuwenhoek. 2002 Aug;82(1-4):249-61. Antonie Van Leeuwenhoek. 2002. PMID: 12369191 Review.
• Anaerobic sugar catabolism in Lactococcus lactis: genetic regulation and enzyme control over pathway flux.
  Cocaign-Bousquet M, Even S, Lindley ND, Loubière P. Cocaign-Bousquet M, et al. Appl Microbiol Biotechnol. 2002 Oct;60(1-2):24-32. doi: 10.1007/s00253-002-1065-x. Epub 2002 Sep 4. Appl Microbiol Biotechnol. 2002. PMID: 12382039 Review.
• The metabolic pH response in Lactococcus lactis: an integrative experimental and modelling approach.
  Andersen AZ, Carvalho AL, Neves AR, Santos H, Kummer U, Olsen LF. Andersen AZ, et al. Comput Biol Chem. 2009 Feb;33(1):71-83. doi: 10.1016/j.compbiolchem.2008.08.001. Epub 2008 Aug 14. Comput Biol Chem. 2009. PMID: 18829387
• [Carbohydrate metabolism and lactic acid biosynthesis of Lactococcus lactis subsp. lactis KLDS4.0325].
  Yang X, Wang Y, Zhou Y, Gao X, Bailiang L, Huo G. Yang X, et al. Wei Sheng Wu Xue Bao. 2014 Oct 4;54(10):1146-54. Wei Sheng Wu Xue Bao. 2014. PMID: 25803891 Chinese.
• Role of phosphate in the central metabolism of two lactic acid bacteria--a comparative systems biology approach.
  Levering J, Musters MW, Bekker M, Bellomo D, Fiedler T, de Vos WM, Hugenholtz J, Kreikemeyer B, Kummer U, Teusink B. Levering J, et al. FEBS J. 2012 Apr;279(7):1274-90. doi: 10.1111/j.1742-4658.2012.08523.x. Epub 2012 Mar 12. FEBS J. 2012. PMID: 22325620

Cited by

• Metabolic shifts: a fitness perspective for microbial cell factories.
  Goel A, Wortel MT, Molenaar D, Teusink B. Goel A, et al. Biotechnol Lett. 2012 Dec;34(12):2147-60. doi: 10.1007/s10529-012-1038-9. Epub 2012 Aug 31. Biotechnol Lett. 2012. PMID: 22936303 Free PMC article. Review.
• Pyruvate formate lyase is required for pneumococcal fermentative metabolism and virulence.
  Yesilkaya H, Spissu F, Carvalho SM, Terra VS, Homer KA, Benisty R, Porat N, Neves AR, Andrew PW. Yesilkaya H, et al. Infect Immun. 2009 Dec;77(12):5418-27. doi: 10.1128/IAI.00178-09. Epub 2009 Sep 14. Infect Immun. 2009. PMID: 19752030 Free PMC article.
• In-Cell NMR: Analysis of Protein-Small Molecule Interactions, Metabolic Processes, and Protein Phosphorylation.
  Kumar A, Kuhn LT, Balbach J. Kumar A, et al. Int J Mol Sci. 2019 Jan 17;20(2):378. doi: 10.3390/ijms20020378. Int J Mol Sci. 2019. PMID: 30658393 Free PMC article. Review.
• The Lcn972 bacteriocin-encoding plasmid pBL1 impairs cellobiose metabolism in Lactococcus lactis.
  Campelo AB, Gaspar P, Roces C, Rodríguez A, Kok J, Kuipers OP, Neves AR, Martínez B. Campelo AB, et al. Appl Environ Microbiol. 2011 Nov;77(21):7576-85. doi: 10.1128/AEM.06107-11. Epub 2011 Sep 2. Appl Environ Microbiol. 2011. PMID: 21890668 Free PMC article.
• Recent developments in parameter estimation and structure identification of biochemical and genomic systems.
  Chou IC, Voit EO. Chou IC, et al. Math Biosci. 2009 Jun;219(2):57-83. doi: 10.1016/j.mbs.2009.03.002. Epub 2009 Mar 25. Math Biosci. 2009. PMID: 19327372 Free PMC article. Review.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • CORE
  • Silverchair Information Systems
  • Wiley

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc