Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability - PubMed (original) (raw)

Review

Kv2.1: a voltage-gated k+ channel critical to dynamic control of neuronal excitability

Hiroaki Misonou et al. Neurotoxicology. 2005 Oct.

Abstract

Neurons use a variety of mechanisms to dynamically control their own signaling capabilities. Regulation of voltage-dependent K+ channel localization and function has long been recognized as a major mechanism to achieve dynamic regulation of intrinsic neuronal excitability in a number of mammalian and non-mammalian neurons. Our recent evidence, together with compelling data from other laboratories, suggests that in mammalian neurons the Kv2.1 channel may play an especially prominent role in determining intrinsic neuronal excitability. Kv2.1 is widely expressed in brain and composes the majority of delayed rectifier K+ current in pyramidal neurons in cortex and hippocampus, and is also widely expressed in interneurons. Dynamic modulation of Kv2.1 localization and function by a mechanism involving activity-dependent Kv2.1 dephosphorylation dramatically impacts intrinsic excitability of neurons. Here we review previous studies of Kv2.1 localization and function in neurons, and summarize recent work regarding dynamic regulation of these characteristics. We also discuss possible roles of the Kv2.1 channel in neuronal and network excitability.

PubMed Disclaimer

Similar articles

• Regulation of ion channel localization and phosphorylation by neuronal activity.
  Misonou H, Mohapatra DP, Park EW, Leung V, Zhen D, Misonou K, Anderson AE, Trimmer JS. Misonou H, et al. Nat Neurosci. 2004 Jul;7(7):711-8. doi: 10.1038/nn1260. Epub 2004 Jun 13. Nat Neurosci. 2004. PMID: 15195093
• Comparison of the endogenous IK currents in rat hippocampal neurons and cloned Kv2.1 channels in CHO cells.
  Liu M, Gong B, Qi Z. Liu M, et al. Cell Biol Int. 2008 Dec;32(12):1514-20. doi: 10.1016/j.cellbi.2008.08.019. Epub 2008 Aug 30. Cell Biol Int. 2008. PMID: 18801450
• The Kv2.1 C terminus can autonomously transfer Kv2.1-like phosphorylation-dependent localization, voltage-dependent gating, and muscarinic modulation to diverse Kv channels.
  Mohapatra DP, Trimmer JS. Mohapatra DP, et al. J Neurosci. 2006 Jan 11;26(2):685-95. doi: 10.1523/JNEUROSCI.4620-05.2006. J Neurosci. 2006. PMID: 16407566 Free PMC article.
• Dynamic regulation of the voltage-gated Kv2.1 potassium channel by multisite phosphorylation.
  Mohapatra DP, Park KS, Trimmer JS. Mohapatra DP, et al. Biochem Soc Trans. 2007 Nov;35(Pt 5):1064-8. doi: 10.1042/BST0351064. Biochem Soc Trans. 2007. PMID: 17956280 Review.
• Determinants of voltage-gated potassium channel surface expression and localization in Mammalian neurons.
  Misonou H, Trimmer JS. Misonou H, et al. Crit Rev Biochem Mol Biol. 2004 May-Jun;39(3):125-45. doi: 10.1080/10409230490475417. Crit Rev Biochem Mol Biol. 2004. PMID: 15596548 Review.

Cited by

• Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells.
  Dixon RE, Trimmer JS. Dixon RE, et al. Annu Rev Physiol. 2023 Feb 10;85:217-243. doi: 10.1146/annurev-physiol-032122-104610. Epub 2022 Oct 6. Annu Rev Physiol. 2023. PMID: 36202100 Free PMC article. Review.
• The anticonvulsant retigabine suppresses neuronal KV2-mediated currents.
  Stas JI, Bocksteins E, Jensen CS, Schmitt N, Snyders DJ. Stas JI, et al. Sci Rep. 2016 Oct 13;6:35080. doi: 10.1038/srep35080. Sci Rep. 2016. PMID: 27734968 Free PMC article.
• Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS).
  Mavlyutov TA, Guo LW, Epstein ML, Ruoho AE. Mavlyutov TA, et al. J Pharmacol Sci. 2015 Jan;127(1):10-6. doi: 10.1016/j.jphs.2014.12.013. Epub 2015 Jan 5. J Pharmacol Sci. 2015. PMID: 25704013 Free PMC article. Review.
• Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum-Plasma Membrane Junctions in Mammalian Brain Neurons.
  Kirmiz M, Vierra NC, Palacio S, Trimmer JS. Kirmiz M, et al. J Neurosci. 2018 Aug 29;38(35):7562-7584. doi: 10.1523/JNEUROSCI.0893-18.2018. Epub 2018 Jul 16. J Neurosci. 2018. PMID: 30012696 Free PMC article.
• Kv2 subunits underlie slowly inactivating potassium current in rat neocortical pyramidal neurons.
  Guan D, Tkatch T, Surmeier DJ, Armstrong WE, Foehring RC. Guan D, et al. J Physiol. 2007 Jun 15;581(Pt 3):941-60. doi: 10.1113/jphysiol.2007.128454. Epub 2007 Mar 22. J Physiol. 2007. PMID: 17379638 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information