Expression of MCT1, MCT2 and MCT4 in the rumen, small intestine and liver of reindeer (Rangifer tarandus tarandus L.) - PubMed (original) (raw)
Expression of MCT1, MCT2 and MCT4 in the rumen, small intestine and liver of reindeer (Rangifer tarandus tarandus L.)
Ninna Koho et al. Comp Biochem Physiol A Mol Integr Physiol. 2005 May.
Abstract
The expression of monocarboxylate transporters MCT1, MCT2 and MCT4 in the rumen, small intestine and liver was examined in free-ranging and captive reindeer. In addition, expression of chaperone protein CD147, which is needed for the activity of MCT1 and MCT4, was studied in the rumen of suckling calves. Immunoblotting of cell membrane proteins showed the expression of MCT1 and MCT4, but not that of MCT2 in the rumen of reindeer. In free-ranging reindeer the amount of MCT1 was higher than in the captive ones (P<0.01). Developing rumen of suckling calves expressed MCT1 and MCT4 and positive correlation was found between MCT1 and CD147. Both MCT1 and CD147 correlated also with age in calves less than 10 days. In the small intestine all the isoforms studied were expressed, but the amounts were lower than in the rumen (P<0.05). In the liver MCT1 and MCT2 were found while MCT4 was nearly undetectable. The expression of MCT isoforms in the rumen and small intestine reflects the site of absorption and concentrations of short chain fatty acids (SCFA). In the liver the expression of high affinity transporters, MCT1 and MCT2, is in accordance with almost complete uptake of propionate from portal blood.
Similar articles
- Expression of CD147 and monocarboxylate transporters MCT1, MCT2 and MCT4 in porcine small intestine and colon.
Sepponen K, Ruusunen M, Pakkanen JA, Pösö AR. Sepponen K, et al. Vet J. 2007 Jul;174(1):122-8. doi: 10.1016/j.tvjl.2006.05.015. Epub 2006 Aug 9. Vet J. 2007. PMID: 16901736 - Expression of lactate transporters MCT1, MCT2 and CD147 in the red blood cells of three horse breeds: Finnhorse, Standardbred and Thoroughbred.
Mykkänen AK, Pösö AR, McGowan CM, McKane SA. Mykkänen AK, et al. Equine Vet J Suppl. 2010 Nov;(38):161-6. doi: 10.1111/j.2042-3306.2010.00205.x. Equine Vet J Suppl. 2010. PMID: 21059000 - The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells.
Wang Q, Morris ME. Wang Q, et al. Drug Metab Dispos. 2007 Aug;35(8):1393-9. doi: 10.1124/dmd.107.014852. Epub 2007 May 14. Drug Metab Dispos. 2007. PMID: 17502341 - Monocarboxylate transporters in the central nervous system: distribution, regulation and function.
Pierre K, Pellerin L. Pierre K, et al. J Neurochem. 2005 Jul;94(1):1-14. doi: 10.1111/j.1471-4159.2005.03168.x. J Neurochem. 2005. PMID: 15953344 Review. - The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.
Halestrap AP, Price NT. Halestrap AP, et al. Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):281-99. Biochem J. 1999. PMID: 10510291 Free PMC article. Review.
Cited by
- A comparative study on the expression profile of MCTs and HSPs in Ghungroo and Large White Yorkshire breeds of pigs during different seasons.
Parkunan T, Banerjee D, Mohanty N, Das PK, Ghosh P, Mukherjee J, Paul A, Das AK, Nanda PK, Naskar S, Mohan NH, Sarkar M, Das BC. Parkunan T, et al. Cell Stress Chaperones. 2015 May;20(3):441-9. doi: 10.1007/s12192-014-0569-5. Epub 2015 Jan 26. Cell Stress Chaperones. 2015. PMID: 25618330 Free PMC article. - Preclinical Incorporation Dosimetry of [18F]FACH-A Novel 18F-Labeled MCT1/MCT4 Lactate Transporter Inhibitor for Imaging Cancer Metabolism with PET.
Sattler B, Kranz M, Wenzel B, Jain NT, Moldovan RP, Toussaint M, Deuther-Conrad W, Ludwig FA, Teodoro R, Sattler T, Sadeghzadeh M, Sabri O, Brust P. Sattler B, et al. Molecules. 2020 Apr 26;25(9):2024. doi: 10.3390/molecules25092024. Molecules. 2020. PMID: 32357571 Free PMC article. - A Designer Synbiotic Attenuates Chronic-Binge Ethanol-Induced Gut-Liver Injury in Mice.
Roychowdhury S, Glueck B, Han Y, Mohammad MA, Cresci GAM. Roychowdhury S, et al. Nutrients. 2019 Jan 5;11(1):97. doi: 10.3390/nu11010097. Nutrients. 2019. PMID: 30621265 Free PMC article. - Effect of Tea Tree Oil on the Expression of Genes Involved in the Innate Immune System in Goat Rumen Epithelial Cells.
Hu Z, Lin M, Ma X, Zhao G, Zhan K. Hu Z, et al. Animals (Basel). 2021 Aug 21;11(8):2460. doi: 10.3390/ani11082460. Animals (Basel). 2021. PMID: 34438917 Free PMC article. - Plasma membrane protein polarity and trafficking in RPE cells: past, present and future.
Lehmann GL, Benedicto I, Philp NJ, Rodriguez-Boulan E. Lehmann GL, et al. Exp Eye Res. 2014 Sep;126:5-15. doi: 10.1016/j.exer.2014.04.021. Exp Eye Res. 2014. PMID: 25152359 Free PMC article. Review.