Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop - PubMed (original) (raw)
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
Sumanta Goswami et al. Cancer Res. 2005.
Erratum in
- Cancer Res. 2005 Aug 1;65(15):7031
Abstract
Previous studies have shown that macrophages and tumor cells are comigratory in mammary tumors and that these cell types are mutually dependent for invasion. Here we show that macrophages and tumor cells are necessary and sufficient for comigration and invasion into collagen I and that this process involves a paracrine loop. Macrophages express epidermal growth factor (EGF), which promotes the formation of elongated protrusions and cell invasion by carcinoma cells. Colony stimulating factor 1 (CSF-1) produced by carcinoma cells promotes the expression of EGF by macrophages. In addition, EGF promotes the expression of CSF-1 by carcinoma cells thereby generating a positive feedback loop. Disruption of this loop by blockade of either EGF receptor or CSF-1 receptor signaling is sufficient to inhibit both macrophage and tumor cell migration and invasion.
Similar articles
- Invasion of human breast cancer cells in vivo requires both paracrine and autocrine loops involving the colony-stimulating factor-1 receptor.
Patsialou A, Wyckoff J, Wang Y, Goswami S, Stanley ER, Condeelis JS. Patsialou A, et al. Cancer Res. 2009 Dec 15;69(24):9498-506. doi: 10.1158/0008-5472.CAN-09-1868. Cancer Res. 2009. PMID: 19934330 Free PMC article. - A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors.
Wyckoff J, Wang W, Lin EY, Wang Y, Pixley F, Stanley ER, Graf T, Pollard JW, Segall J, Condeelis J. Wyckoff J, et al. Cancer Res. 2004 Oct 1;64(19):7022-9. doi: 10.1158/0008-5472.CAN-04-1449. Cancer Res. 2004. PMID: 15466195 - Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling.
Coniglio SJ, Eugenin E, Dobrenis K, Stanley ER, West BL, Symons MH, Segall JE. Coniglio SJ, et al. Mol Med. 2012 May 9;18(1):519-27. doi: 10.2119/molmed.2011.00217. Mol Med. 2012. PMID: 22294205 Free PMC article. - Is colony-stimulating factor-1 a key mediator of breast cancer invasion and metastasis?
Scholl SM, Crocker P, Tang R, Pouillart P, Pollard JW. Scholl SM, et al. Mol Carcinog. 1993;7(4):207-11. doi: 10.1002/mc.2940070402. Mol Carcinog. 1993. PMID: 8352880 Review. No abstract available. - CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract.
Kacinski BM. Kacinski BM. Mol Reprod Dev. 1997 Jan;46(1):71-4. doi: 10.1002/(SICI)1098-2795(199701)46:1<71::AID-MRD11>3.0.CO;2-6. Mol Reprod Dev. 1997. PMID: 8981366 Review.
Cited by
- Analysis of neuroglia and immune cells in the tumor microenvironment of breast cancer brain metastasis.
Mo H, Zhang X, Ren L. Mo H, et al. Cancer Biol Ther. 2024 Dec 31;25(1):2398285. doi: 10.1080/15384047.2024.2398285. Epub 2024 Sep 5. Cancer Biol Ther. 2024. PMID: 39238191 Free PMC article. Review. - JDF promotes the apoptosis of M2 macrophages and reduces epithelial-mesenchymal transition and migration of liver cancer cells by inhibiting CSF-1/PI3K/AKT signaling pathway.
Liu X, Wang Z, Lv X, Tao Z, Lin L, Zhao S, Zhang K, Li Y. Liu X, et al. Heliyon. 2024 Aug 2;10(15):e34968. doi: 10.1016/j.heliyon.2024.e34968. eCollection 2024 Aug 15. Heliyon. 2024. PMID: 39170340 Free PMC article. - Phenotypic Heterogeneity, Bidirectionality, Universal Cues, Plasticity, Mechanics, and the Tumor Microenvironment Drive Cancer Metastasis.
Mierke CT. Mierke CT. Biomolecules. 2024 Feb 3;14(2):184. doi: 10.3390/biom14020184. Biomolecules. 2024. PMID: 38397421 Free PMC article. Review. - A promising target for breast cancer: B7-H3.
Jiang Y, Liu J, Chen L, Qian Z, Zhang Y. Jiang Y, et al. BMC Cancer. 2024 Feb 7;24(1):182. doi: 10.1186/s12885-024-11933-3. BMC Cancer. 2024. PMID: 38326735 Free PMC article. Review. - Signaling events at TMEM doorways provide potential targets for inhibiting breast cancer dissemination.
Surve CR, Duran CL, Ye X, Chen X, Lin Y, Harney AS, Wang Y, Sharma VP, Stanley ER, Cox D, McAuliffe JC, Entenberg D, Oktay MH, Condeelis JS. Surve CR, et al. bioRxiv [Preprint]. 2024 Mar 7:2024.01.08.574676. doi: 10.1101/2024.01.08.574676. bioRxiv. 2024. PMID: 38260319 Free PMC article. Preprint.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous