Neurosteroids: endogenous regulators of the GABA(A) receptor - PubMed (original) (raw)
Review
doi: 10.1038/nrn1703.
Affiliations
- PMID: 15959466
- DOI: 10.1038/nrn1703
Review
Neurosteroids: endogenous regulators of the GABA(A) receptor
Delia Belelli et al. Nat Rev Neurosci. 2005 Jul.
Abstract
GABA(A) (gamma-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are targeted by many clinically important drugs. Certain naturally occurring pregnane steroids can potently and specifically enhance GABA(A) receptor function in a nongenomic (direct) manner, and consequently have anxiolytic, analgesic, anticonvulsant, sedative, hypnotic and anaesthetic properties. These steroids not only act as remote endocrine messengers, but also can be synthesized in the brain, where they modify neuronal activity locally by modulating GABA(A) receptor function. Such 'neurosteroids' can influence mood and behaviour in various physiological and pathophysiological situations, and might contribute to the behavioural effects of psychoactive drugs.
Similar articles
- Neuroactive steroids and inhibitory neurotransmission: mechanisms of action and physiological relevance.
Belelli D, Herd MB, Mitchell EA, Peden DR, Vardy AW, Gentet L, Lambert JJ. Belelli D, et al. Neuroscience. 2006;138(3):821-9. doi: 10.1016/j.neuroscience.2005.07.021. Epub 2005 Nov 28. Neuroscience. 2006. PMID: 16310966 Review. - Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors.
Farrant M, Nusser Z. Farrant M, et al. Nat Rev Neurosci. 2005 Mar;6(3):215-29. doi: 10.1038/nrn1625. Nat Rev Neurosci. 2005. PMID: 15738957 Review. - Neurosteroid modulation of synaptic and extrasynaptic GABA(A) receptors.
Herd MB, Belelli D, Lambert JJ. Herd MB, et al. Pharmacol Ther. 2007 Oct;116(1):20-34. doi: 10.1016/j.pharmthera.2007.03.007. Epub 2007 Apr 21. Pharmacol Ther. 2007. PMID: 17531325 Review. - Endogenous gamma-aminobutyric acid (GABA)(A) receptor active neurosteroids and the sedative/hypnotic action of gamma-hydroxybutyric acid (GHB): a study in GHB-S (sensitive) and GHB-R (resistant) rat lines.
Barbaccia ML, Carai MA, Colombo G, Lobina C, Purdy RH, Gessa GL. Barbaccia ML, et al. Neuropharmacology. 2005 Jul;49(1):48-58. doi: 10.1016/j.neuropharm.2005.01.026. Epub 2005 Mar 31. Neuropharmacology. 2005. PMID: 15992580
Cited by
- Forskolin reverses the O-GlcNAcylation dependent decrease in GABAAR current amplitude at hippocampal synapses possibly at a neurosteroid site on GABAARs.
Phillips S, Chatham JC, McMahon LL. Phillips S, et al. Sci Rep. 2024 Jul 29;14(1):17461. doi: 10.1038/s41598-024-66025-w. Sci Rep. 2024. PMID: 39075105 Free PMC article. - Neurosteroid Modulation of Synaptic and Extrasynaptic GABAA Receptors of the Mouse Nucleus Accumbens.
Mitchell SJ, Phillips GD, Tench B, Li Y, Belelli D, Martin SJ, Swinny JD, Kelly L, Atack JR, Paradowski M, Lambert JJ. Mitchell SJ, et al. Biomolecules. 2024 Apr 9;14(4):460. doi: 10.3390/biom14040460. Biomolecules. 2024. PMID: 38672476 Free PMC article. - Forskolin reverses the O-GlcNAcylation dependent decrease in GABAAR current amplitude at hippocampal synapses possibly at a neurosteroid site on GABAARs.
Phillips S, Chatham JC, McMahon LL. Phillips S, et al. Res Sq [Preprint]. 2024 Apr 10:rs.3.rs-4140038. doi: 10.21203/rs.3.rs-4140038/v1. Res Sq. 2024. PMID: 38659738 Free PMC article. Updated. Preprint. - Key mRNAs and lncRNAs of pituitary that affect the reproduction of FecB + + small tail han sheep.
Yang J, Tang J, He X, Di R, Zhang X, Zhang J, Guo X, Hu W, Chu M. Yang J, et al. BMC Genomics. 2024 Apr 22;25(1):392. doi: 10.1186/s12864-024-10191-8. BMC Genomics. 2024. PMID: 38649819 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases