Broader distribution of plasmid-mediated quinolone resistance in the United States - PubMed (original) (raw)

Broader distribution of plasmid-mediated quinolone resistance in the United States

A Robicsek et al. Antimicrob Agents Chemother. 2005 Jul.

Abstract

The plasmid-encoded quinolone resistance gene qnrA confers low-level quinolone resistance, facilitating selection of higher-level resistance. Epidemiologic surveys for qnrA were extended to isolates of Enterobacter spp. and to quinolone-susceptible Enterobacteriaceae. Two (10%) of 20 ceftazidime-resistant quinolone-susceptible Klebsiella pneumoniae strains carried the gene, as did 12 (17%) of 71 ceftazidime-resistant Enterobacter strains from across the United States. One of these Enterobacter isolates was quinolone susceptible. Thus, qnrA is present in quinolone-resistant and quinolone-susceptible Enterobacter and Klebsiella strains in the United States.

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Figures

FIG. 1.

Comparison of the regions flanking qnrA in pHSH2 from Shanghai E. coli isolates (a) with those from pMG252 and plasmids from E. cloacae isolates (b) in this study. The regions differ in that plasmids in panel b include a 76-bp noncoding element upstream of qnrA and lack ampR relative to pHSH2. qacE_Δ_1, a deletion mutant of the gacE gene, which encodes the QacE efflux pump.

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