Naturally arising CD25+CD4+ regulatory T cells in tumor immunity - PubMed (original) (raw)

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Naturally arising CD25+CD4+ regulatory T cells in tumor immunity

T Nomura et al. Curr Top Microbiol Immunol. 2005.

Abstract

Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer.

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