Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans - PubMed (original) (raw)

Comparative Study

Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans

Lloyd Demetrius. EMBO Rep. 2005 Jul.

Abstract

When it comes to studying ageing and the means to slow it down, mice are not just small humans

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Figures

Figure 1

Figure 1

Survivorship distribution for laboratory mice and an industrialized human population.

Figure 2

Figure 2

Fecundity distribution for laboratory mice and an industrialized human population.

Figure 3

Figure 3

The net fecundity distribution V(x) = l(x)m(x) for laboratory mice and humans. The curve for mice describes a population with early age of sexual maturity, large litter size and narrow reproductive span (low entropy) whereas that for humans shows the effect of late age of sexual maturity, small litter size and broad reproductive span (large entropy).

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References

    1. Austad SN (1997) Comparative aging and life histories in mammals. Exp Gerontol 32: 22–38 - PubMed
    1. Balmain A, Harris CC (2000) Carcinogenesis in mouse and human cells: parallels and paradoxes. Carcinogenesis 21: 371–377 - PubMed
    1. Beckman KB, Ames BN (1998) The free radical theory of aging matures. Physiol Rev 78: 547–581 - PubMed
    1. Cao SX, Dhahbi JM, Mote PL, Spindler SR (2001) Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice. Proc Natl Acad Sci USA 98: 10630–10635 - PMC - PubMed
    1. Cutler RG (1984) Antioxidants, aging and longevity. In Pryor WA (ed) Free Radicals in Biology (vol 6) pp371–428. New York, NY, USA: Academic

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