Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid - PubMed (original) (raw)
Randomized Controlled Trial
. 2005 Dec;289(6):E948-53.
doi: 10.1152/ajpendo.00220.2005. Epub 2005 Jul 5.
Affiliations
- PMID: 15998659
- DOI: 10.1152/ajpendo.00220.2005
Free article
Randomized Controlled Trial
Fat digestion is required for suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide secretion by intraduodenal lipid
Christine Feinle-Bisset et al. Am J Physiol Endocrinol Metab. 2005 Dec.
Free article
Abstract
Stimulation of cholecystokinin and glucagon-like peptide-1 secretion by fat is mediated by the products of fat digestion. Ghrelin, peptide YY (PYY), and pancreatic polypeptide (PP) appear to play an important role in appetite regulation, and their release is modulated by food ingestion, including fat. It is unknown whether fat digestion is a prerequisite for their suppression (ghrelin) or release (PYY, PP). Moreover, it is not known whether small intestinal exposure to fat is sufficient to suppress ghrelin secretion. Our study aimed to resolve these issues. Sixteen healthy young males received, on two separate occasions, 120-min intraduodenal infusions of a long-chain triglyceride emulsion (2.8 kcal/min) 1) without (condition FAT) or 2) with (FAT-THL) 120 mg of tetrahydrolipstatin (THL, lipase inhibitor), followed by a standard buffet-style meal. Blood samples for ghrelin, PYY, and PP were taken throughout. FAT infusion was associated with a marked, and progressive, suppression of plasma ghrelin from t = 60 min (P < 0.001) and stimulation of PYY from t = 30 min (P < 0.01). FAT infusion also stimulated plasma PP (P < or = 0.01), and the release was immediate. FAT-THL completely abolished the FAT-induced changes in ghrelin, PYY, and PP. In response to the meal, plasma ghrelin was further suppressed, and PYY and PP stimulated, during both FAT and FAT-THL infusions. In conclusion, in healthy humans, 1) the presence of fat in the small intestine suppresses ghrelin secretion, and 2) fat-induced suppression of ghrelin and stimulation of PYY and PP is dependent on fat digestion.
Similar articles
- Effect of fatty acid chain length on suppression of ghrelin and stimulation of PYY, GLP-2 and PP secretion in healthy men.
Feltrin KL, Patterson M, Ghatei MA, Bloom SR, Meyer JH, Horowitz M, Feinle-Bisset C. Feltrin KL, et al. Peptides. 2006 Jul;27(7):1638-43. doi: 10.1016/j.peptides.2006.01.023. Epub 2006 Mar 23. Peptides. 2006. PMID: 16563563 - Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans.
Feinle C, O'Donovan D, Doran S, Andrews JM, Wishart J, Chapman I, Horowitz M. Feinle C, et al. Am J Physiol Gastrointest Liver Physiol. 2003 May;284(5):G798-807. doi: 10.1152/ajpgi.00512.2002. Epub 2003 Jan 10. Am J Physiol Gastrointest Liver Physiol. 2003. PMID: 12684211 Clinical Trial. - Intravenous CCK-8, but not GLP-1, suppresses ghrelin and stimulates PYY release in healthy men.
Brennan IM, Otto B, Feltrin KL, Meyer JH, Horowitz M, Feinle-Bisset C. Brennan IM, et al. Peptides. 2007 Mar;28(3):607-11. doi: 10.1016/j.peptides.2006.10.014. Epub 2006 Nov 28. Peptides. 2007. PMID: 17129639 - Gastrointestinal hormones and regulation of food intake.
Dhillo WS, Bloom SR. Dhillo WS, et al. Horm Metab Res. 2004 Nov-Dec;36(11-12):846-51. doi: 10.1055/s-2004-826174. Horm Metab Res. 2004. PMID: 15655718 Review. - Gut hormones and the control of appetite.
Small CJ, Bloom SR. Small CJ, et al. Trends Endocrinol Metab. 2004 Aug;15(6):259-63. doi: 10.1016/j.tem.2004.06.002. Trends Endocrinol Metab. 2004. PMID: 15358278 Review.
Cited by
- Involvement of the vagus nerve in the anorectic effect of monoacylglycerol acyltransferase 2 inhibition in mice.
Takemoto K, Kato H, Higashino K. Takemoto K, et al. Obes Sci Pract. 2023 Jul 6;9(6):601-608. doi: 10.1002/osp4.693. eCollection 2023 Dec. Obes Sci Pract. 2023. PMID: 38090688 Free PMC article. - Fatty Acid Sensing in the Gastrointestinal Tract of Rainbow Trout: Different to Mammalian Model?
Calo J, Comesaña S, Alonso-Gómez ÁL, Soengas JL, Blanco AM. Calo J, et al. Int J Mol Sci. 2023 Feb 21;24(5):4275. doi: 10.3390/ijms24054275. Int J Mol Sci. 2023. PMID: 36901706 Free PMC article. - Acute feeding with almonds compared to a carbohydrate-based snack improves appetite-regulating hormones with no effect on self-reported appetite sensations: a randomised controlled trial.
Carter S, Hill AM, Buckley JD, Tan SY, Rogers GB, Coates AM. Carter S, et al. Eur J Nutr. 2023 Mar;62(2):857-866. doi: 10.1007/s00394-022-03027-2. Epub 2022 Oct 28. Eur J Nutr. 2023. PMID: 36305961 Free PMC article. Clinical Trial. - Dietary Fat Chain Length, Saturation, and PUFA Source Acutely Affect Diet-Induced Thermogenesis but Not Satiety in Adults in a Randomized, Crossover Trial.
Rust BM, Raatz SK, Casperson SL, Duke SE, Picklo MJ. Rust BM, et al. Nutrients. 2021 Jul 29;13(8):2615. doi: 10.3390/nu13082615. Nutrients. 2021. PMID: 34444773 Free PMC article. Clinical Trial. - The Effect of High-Fat Diet-Induced Obesity on the Expression of Nutrient Chemosensors in the Mouse Stomach and the Gastric Ghrelin Cell.
Nunez-Salces M, Li H, Christie S, Page AJ. Nunez-Salces M, et al. Nutrients. 2020 Aug 19;12(9):2493. doi: 10.3390/nu12092493. Nutrients. 2020. PMID: 32824949 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous