New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions - PubMed (original) (raw)

Review

doi: 10.1038/nri1648.

Affiliations

• PMID: 15999093
• DOI: 10.1038/nri1648

Review

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

Christopher A Hunter. Nat Rev Immunol. 2005 Jul.

Abstract

Understanding the factors that influence T helper 1 (T(H)1)- and T(H)2-cell responses has been one of the main focuses of immunology for almost 20 years. Whereas the central role of interleukin-12 (IL-12) in the generation of T(H)1 cells has long been appreciated, subsequent studies indicated that IL-23 and IL-27, two cytokines that are closely related to IL-12, also regulate T(H)1-cell responses. However, as discussed in this article, it is now recognized that the ability of IL-23 to stimulate a unique T-cell subset to produce IL-17 has a dominant role in autoimmune inflammation. By contrast, IL-27 has a role in limiting the intensity and duration of adaptive immune responses.

PubMed Disclaimer

Similar articles

• Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors.
  Becker C, Wirtz S, Neurath MF. Becker C, et al. Inflamm Bowel Dis. 2005 Aug;11(8):755-64. doi: 10.1097/01.mib.0000172808.03877.4d. Inflamm Bowel Dis. 2005. PMID: 16043992 Review.
• The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases.
  Hölscher C. Hölscher C. Med Microbiol Immunol. 2004 Feb;193(1):1-17. doi: 10.1007/s00430-003-0186-x. Epub 2003 Jun 27. Med Microbiol Immunol. 2004. PMID: 12836019 Review.
• Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.
  Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD. Cua DJ, et al. Nature. 2003 Feb 13;421(6924):744-8. doi: 10.1038/nature01355. Nature. 2003. PMID: 12610626
• Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis.
  Touil T, Fitzgerald D, Zhang GX, Rostami AM, Gran B. Touil T, et al. Drug News Perspect. 2006 Mar;19(2):77-83. doi: 10.1358/dnp.2006.19.2.977443. Drug News Perspect. 2006. PMID: 16628262 Review.
• IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12.
  Kleinschek MA, Muller U, Brodie SJ, Stenzel W, Kohler G, Blumenschein WM, Straubinger RK, McClanahan T, Kastelein RA, Alber G. Kleinschek MA, et al. J Immunol. 2006 Jan 15;176(2):1098-106. doi: 10.4049/jimmunol.176.2.1098. J Immunol. 2006. PMID: 16393998

Cited by

• Divergent pro-inflammatory profile of human dendritic cells in response to commensal and pathogenic bacteria associated with the airway microbiota.
  Larsen JM, Steen-Jensen DB, Laursen JM, Søndergaard JN, Musavian HS, Butt TM, Brix S. Larsen JM, et al. PLoS One. 2012;7(2):e31976. doi: 10.1371/journal.pone.0031976. Epub 2012 Feb 21. PLoS One. 2012. PMID: 22363778 Free PMC article.
• A Multidisciplinary Approach to Patients with Psoriasis and a History of Malignancies or On-Treatment for Solid Tumors: A Narrative Literature Review.
  Denaro N, Nazzaro G, Murgia G, Scarfì F, Cauchi C, Carrera CG, Cattaneo A, Solinas C, Scartozzi M, Marzano AV, Garrone O, Passoni E. Denaro N, et al. Int J Mol Sci. 2023 Dec 16;24(24):17540. doi: 10.3390/ijms242417540. Int J Mol Sci. 2023. PMID: 38139369 Free PMC article. Review.
• Cytokines and Chemokines in Mycobacterium tuberculosis Infection.
  Domingo-Gonzalez R, Prince O, Cooper A, Khader SA. Domingo-Gonzalez R, et al. Microbiol Spectr. 2016 Oct;4(5):10.1128/microbiolspec.TBTB2-0018-2016. doi: 10.1128/microbiolspec.TBTB2-0018-2016. Microbiol Spectr. 2016. PMID: 27763255 Free PMC article. Review.
• Thymic DCs derived IL-27 regulates the final maturation of CD4(+) SP thymocytes.
  Tang H, Zhang J, Sun X, Qian X, Zhang Y, Jin R. Tang H, et al. Sci Rep. 2016 Jul 29;6:30448. doi: 10.1038/srep30448. Sci Rep. 2016. PMID: 27469302 Free PMC article.
• IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells.
  Xu J, Wang Y, Li J, Zhang X, Geng Y, Huang Y, Dai K, Zhang X. Xu J, et al. Cell Death Differ. 2016 Dec;23(12):1941-1951. doi: 10.1038/cdd.2016.72. Epub 2016 Jul 29. Cell Death Differ. 2016. PMID: 27472064 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database