The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire - PubMed (original) (raw)

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doi: 10.1038/nri1649.

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• PMID: 15999097
• DOI: 10.1038/nri1649

Review

The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire

Fritz Melchers. Nat Rev Immunol. 2005 Jul.

Abstract

In this Opinion article, I address the role of the pre-B-cell receptor (pre-BCR) in the development of antigen-specific B cells in terms of immunoglobulin heavy chain (IgH) variable-region repertoire selection, precursor B-cell differentiation and proliferation, and IgH allelic exclusion. Comparisons with the role of the pre-T-cell receptor (pre-TCR) in T-cell development raise provocative questions. Why do B- and T-cell lineages both use a surrogate chain - the surrogate light chain and the pre-TCR alpha-chain, respectively - as a step to develop their repertoires of antigen-recognizing cells? What are the functions of the pre-BCR and pre-TCR in lymphocyte differentiation and antigen-receptor allelic exclusion? This article, together with the accompanying article by Harald von Boehmer, hopes to answer some of these questions.

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Comment on

• Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate.
  von Boehmer H. von Boehmer H. Nat Rev Immunol. 2005 Jul;5(7):571-7. doi: 10.1038/nri1636. Nat Rev Immunol. 2005. PMID: 15999096 Review.

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