Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection - PubMed (original) (raw)
. 2005 Nov 15;106(10):3366-9.
doi: 10.1182/blood-2005-03-1100. Epub 2005 Jul 7.
Nickolas Teigen, Benjamin T Davis, Marylyn M Addo, Todd J Suscovich, Michael T Waring, Hendrik Streeck, Mary N Johnston, Kyle D Staller, M Tauheed Zaman, Xu G Yu, Mathias Lichterfeld, Nesli Basgoz, Eric S Rosenberg, Marcus Altfeld
Affiliations
- PMID: 16002429
- DOI: 10.1182/blood-2005-03-1100
Free article
Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
Galit Alter et al. Blood. 2005.
Free article
Abstract
Natural killer (NK) cells are critical in the first-line defense against viral infections. Chronic HIV-1 infection leads to a perturbation in the NK cell compartment, yet the kinetics of this deregulation and the functional consequences are unclear. Here, we characterized changes in the NK cell compartment longitudinally by multiparameter flow cytometry, starting in acute HIV-1 infection. Acute HIV-1 infection was associated with elevated NK cell numbers, with an expansion of CD3(neg)CD56(dim)CD16(pos) NK cells and an early depletion of CD3(neg)CD56(bright)CD16(neg) NK cells. Ongoing viral replication resulted in a depletion of CD3(neg)CD56(dim)CD16(pos) NK cells with a paralleled increase in functionally anergic CD3(neg)CD56(neg)CD16(pos) NK cells, accompanied by reduced functional activity, as measured by CD107a expression and cytokine secretion. Taken together, these studies demonstrate a sequential impairment of NK cell function with persistent viral replication resulting from a progressive deregulation of NK cell subsets with distinct functional properties.
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