Hypoxia-responsive transcription factors - PubMed (original) (raw)

Review

. 2005 Sep;450(6):363-71.

doi: 10.1007/s00424-005-1413-7. Epub 2005 Jul 9.

Affiliations

• PMID: 16007431
• DOI: 10.1007/s00424-005-1413-7

Review

Hypoxia-responsive transcription factors

Eoin P Cummins et al. Pflugers Arch. 2005 Sep.

Abstract

Hypoxia is a common pathophysiological occurrence with a profound impact on the cellular transcriptome. The consequences of hypoxia-induced or hypoxia-repressed gene expression have important implications in disease processes as diverse as tumour development and chronic inflammation. While the hypoxia-inducible factor (HIF-1) plays a major role in controlling the ubiquitous transcriptional response to hypoxia, it is clear that a number of other transcription factors are also activated either directly or indirectly. In this review, we comprehensively discuss the transcription factors that have been reported to be hypoxia-responsive and the signalling mechanisms leading to their activation. Understanding such events will enhance our understanding of cellular oxygen sensing.

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