Have we found the tip link, transduction channel, and gating spring of the hair cell? - PubMed (original) (raw)
Review
Have we found the tip link, transduction channel, and gating spring of the hair cell?
Peter G Gillespie et al. Curr Opin Neurobiol. 2005 Aug.
Abstract
Recent reports have offered candidates for key components of the apparatus used for mechanotransduction in hair cells. TRPA1 and cadherin 23 have been proposed to be the transduction channel and component of the tip link, respectively; moreover, ankyrin repeats in TRPA1 have been proposed to be the gating spring. Although these are excellent candidates for the three components, definitive experiments supporting each identification have yet to be performed.
Similar articles
- Hair bundles: keeping it together.
LeMasurier M, Gillespie PG. LeMasurier M, et al. Nat Neurosci. 2007 Jan;10(1):11-2. doi: 10.1038/nn0107-11. Nat Neurosci. 2007. PMID: 17189944 No abstract available. - In search of the hair-cell gating spring elastic properties of ankyrin and cadherin repeats.
Sotomayor M, Corey DP, Schulten K. Sotomayor M, et al. Structure. 2005 Apr;13(4):669-82. doi: 10.1016/j.str.2005.03.001. Structure. 2005. PMID: 15837205 - Bottoms up: transduction channels at tip link bases.
Spinelli KJ, Gillespie PG. Spinelli KJ, et al. Nat Neurosci. 2009 May;12(5):529-30. doi: 10.1038/nn0509-529. Nat Neurosci. 2009. PMID: 19396230 No abstract available. - Fishing for key players in mechanotransduction.
Nicolson T. Nicolson T. Trends Neurosci. 2005 Mar;28(3):140-4. doi: 10.1016/j.tins.2004.12.008. Trends Neurosci. 2005. PMID: 15749167 Review. - Localisation of the mechanotransducer channels in mammalian cochlear hair cells provides clues to their gating.
Furness DN, Hackney CM, Evans MG. Furness DN, et al. J Physiol. 2010 Mar 1;588(Pt 5):765-72. doi: 10.1113/jphysiol.2009.179614. Epub 2009 Dec 21. J Physiol. 2010. PMID: 20026619 Free PMC article. Review.
Cited by
- A mechanism for active hearing.
Ren T, Gillespie PG. Ren T, et al. Curr Opin Neurobiol. 2007 Aug;17(4):498-503. doi: 10.1016/j.conb.2007.07.013. Epub 2007 Aug 17. Curr Opin Neurobiol. 2007. PMID: 17707636 Free PMC article. Review. - Feeling the pressure in mammalian somatosensation.
Lumpkin EA, Bautista DM. Lumpkin EA, et al. Curr Opin Neurobiol. 2005 Aug;15(4):382-8. doi: 10.1016/j.conb.2005.06.005. Curr Opin Neurobiol. 2005. PMID: 16023849 Free PMC article. Review. - TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells.
Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. Pan B, et al. Neuron. 2018 Aug 22;99(4):736-753.e6. doi: 10.1016/j.neuron.2018.07.033. Neuron. 2018. PMID: 30138589 Free PMC article. - A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression.
Schneider ME, Dosé AC, Salles FT, Chang W, Erickson FL, Burnside B, Kachar B. Schneider ME, et al. J Neurosci. 2006 Oct 4;26(40):10243-52. doi: 10.1523/JNEUROSCI.2812-06.2006. J Neurosci. 2006. PMID: 17021180 Free PMC article. - Frequency locking in auditory hair cells: Distinguishing between additive and parametric forcing.
Edri Y, Bozovic D, Yochelis A. Edri Y, et al. Europhys Lett. 2016 Oct;116(2):28002. doi: 10.1209/0295-5075/116/28002. Epub 2016 Nov 23. Europhys Lett. 2016. PMID: 33859450 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
- DC 003279/DC/NIDCD NIH HHS/United States
- DC002368/DC/NIDCD NIH HHS/United States
- DC004571/DC/NIDCD NIH HHS/United States
- DC005983/DC/NIDCD NIH HHS/United States
- Intramural NIH HHS/United States
LinkOut - more resources
Full Text Sources
Other Literature Sources