Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external beta-turns - PubMed (original) (raw)
. 2005 Jun 21;3(12):2287-95.
doi: 10.1039/b503014e. Epub 2005 May 10.
Affiliations
- PMID: 16010363
- DOI: 10.1039/b503014e
Synthesis of 5/7-, 5/8- and 5/9-bicyclic lactam templates as constraints for external beta-turns
Heather M E Duggan et al. Org Biomol Chem. 2005.
Abstract
The 5/7-, 5/8- and 5/9-bicyclic lactams 3, 17, 5 and 6 have been synthesised as single diastereoisomers by a route involving ring closing olefin metathesis. The X-ray crystal structure of the amino acid hydrochloride has been carried out and compared to that of the saturated external beta-turn constraint 18.
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