Mapping by admixture linkage disequilibrium: advances, limitations and guidelines - PubMed (original) (raw)
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doi: 10.1038/nrg1657.
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- DOI: 10.1038/nrg1657
Review
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines
Michael W Smith et al. Nat Rev Genet. 2005 Aug.
Abstract
Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although unproven, approach to mapping genetic variants that are involved in human disease. MALD takes advantage of long-range haplotypes that are generated by gene flow among recently admixed ethnic groups, such as African-Americans and Latinos. Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations. It will also require 200-500 times fewer markers, providing a significant economic advantage. The MALD approach is now being applied, with results expected in the near future.
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