Turning signals on and off: GLUT4 traffic in the insulin-signaling highway - PubMed (original) (raw)
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Turning signals on and off: GLUT4 traffic in the insulin-signaling highway
Farah S L Thong et al. Physiology (Bethesda). 2005 Aug.
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- Physiology (Bethesda). 2005 Oct;20:table of contents
Abstract
Insulin stimulation of glucose uptake into skeletal muscle and adipose tissues is achieved by accelerating glucose transporter GLUT4 exocytosis from intracellular compartments to the plasma membrane and minimally reducing its endocytosis. The round trip of GLUT4 is intricately regulated by diverse signaling molecules impinging on specific compartments. Here we highlight the key molecular signals that are turned on and off by insulin to accomplish this task.
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