Activation of p75NTR by proBDNF facilitates hippocampal long-term depression - PubMed (original) (raw)
doi: 10.1038/nn1510. Epub 2005 Jul 17.
Affiliations
- PMID: 16025106
- DOI: 10.1038/nn1510
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Newton H Woo et al. Nat Neurosci. 2005 Aug.
Abstract
Pro- and mature brain-derived neurotrophic factor (BDNF) activate two distinct receptors: p75 neurotrophin receptor (p75(NTR)) and TrkB. Mature BDNF facilitates hippocampal synaptic potentiation through TrkB. Here we report that proBDNF, by activating p75(NTR), facilitates hippocampal long-term depression (LTD). Electron microscopy showed that p75(NTR) localized in dendritic spines, in addition to afferent terminals, of CA1 neurons. Deletion of p75(NTR) in mice selectively impaired the NMDA receptor-dependent LTD, without affecting other forms of synaptic plasticity. p75(NTR-/-) mice also showed a decrease in the expression of NR2B, an NMDA receptor subunit uniquely involved in LTD. Activation of p75(NTR) by proBDNF enhanced NR2B-dependent LTD and NR2B-mediated synaptic currents. These results show a crucial role for proBDNF-p75(NTR) signaling in LTD and its potential mechanism, and together with the finding that mature BDNF promotes synaptic potentiation, suggest a bidirectional regulation of synaptic plasticity by proBDNF and mature BDNF.
Similar articles
- proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus.
Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q, Jing D, Lafrancois JJ, Bath KG, Mark W, Ballon D, Lee FS, Scharfman HE, Hempstead BL. Yang J, et al. Cell Rep. 2014 May 8;7(3):796-806. doi: 10.1016/j.celrep.2014.03.040. Epub 2014 Apr 17. Cell Rep. 2014. PMID: 24746813 Free PMC article. - Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling.
Garad M, Edelmann E, Leßmann V. Garad M, et al. Sci Rep. 2021 Apr 20;11(1):8535. doi: 10.1038/s41598-021-87769-9. Sci Rep. 2021. PMID: 33879805 Free PMC article. - Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes.
Sandoval M, Sandoval R, Thomas U, Spilker C, Smalla KH, Falcon R, Marengo JJ, Calderón R, Saavedra V, Heumann R, Bronfman F, Garner CC, Gundelfinger ED, Wyneken U. Sandoval M, et al. J Neurochem. 2007 Jun;101(6):1672-84. doi: 10.1111/j.1471-4159.2007.04519.x. Epub 2007 Mar 23. J Neurochem. 2007. PMID: 17394529 - BDNF and Hippocampal Synaptic Plasticity.
Leal G, Bramham CR, Duarte CB. Leal G, et al. Vitam Horm. 2017;104:153-195. doi: 10.1016/bs.vh.2016.10.004. Epub 2016 Nov 29. Vitam Horm. 2017. PMID: 28215294 Review. - Circadian control of p75 neurotrophin receptor leads to alternate activation of Nrf2 and c-Rel to reset energy metabolism in astrocytes via brain-derived neurotrophic factor.
Ishii T, Warabi E, Mann GE. Ishii T, et al. Free Radic Biol Med. 2018 May 1;119:34-44. doi: 10.1016/j.freeradbiomed.2018.01.026. Epub 2018 Jan 31. Free Radic Biol Med. 2018. PMID: 29374533 Review.
Cited by
- Interactions between the rabies virus and nicotinic acetylcholine receptors: A potential role in rabies virus induced behavior modifications.
Lian M, Hueffer K, Weltzin MM. Lian M, et al. Heliyon. 2022 Aug 28;8(9):e10434. doi: 10.1016/j.heliyon.2022.e10434. eCollection 2022 Sep. Heliyon. 2022. PMID: 36091963 Free PMC article. Review. - Changes in Spontaneous firing patterns of cerebellar Purkinje cells in p75 knockout mice.
Tian J, Tep C, Zhu MX, Yoon SO. Tian J, et al. Cerebellum. 2013 Jun;12(3):300-3. doi: 10.1007/s12311-012-0439-6. Cerebellum. 2013. PMID: 23307658 Free PMC article. - Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins.
Pallesen LT, Vaegter CB. Pallesen LT, et al. Mol Neurobiol. 2012 Apr;45(2):379-87. doi: 10.1007/s12035-012-8236-2. Mol Neurobiol. 2012. PMID: 22297619 Review. - Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses.
Je HS, Yang F, Ji Y, Nagappan G, Hempstead BL, Lu B. Je HS, et al. Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15924-9. doi: 10.1073/pnas.1207767109. Epub 2012 Sep 10. Proc Natl Acad Sci U S A. 2012. PMID: 23019376 Free PMC article. - Exogenous BDNF enhances the integration of chronically injured axons that regenerate through a peripheral nerve grafted into a chondroitinase-treated spinal cord injury site.
Tom VJ, Sandrow-Feinberg HR, Miller K, Domitrovich C, Bouyer J, Zhukareva V, Klaw MC, Lemay MA, Houlé JD. Tom VJ, et al. Exp Neurol. 2013 Jan;239:91-100. doi: 10.1016/j.expneurol.2012.09.011. Epub 2012 Sep 27. Exp Neurol. 2013. PMID: 23022460 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous