Nutrition is a powerful independent risk factor for coronary heart disease in women--The CORA study: a population-based case-control study - PubMed (original) (raw)

Nutrition is a powerful independent risk factor for coronary heart disease in women--The CORA study: a population-based case-control study

B-C Zyriax et al. Eur J Clin Nutr. 2005 Oct.

Abstract

Background: It is still common practice to rely mostly on drug treatment for preventing cardiovascular disease, although a healthy nutrition has been defined that may prevent most premature cardiovascular events.

Objectives: This research raises the question of the magnitude of the effect of nutrition on cardiovascular disease independent of that of clinical risk factors, which are the targets of drug therapy.

Design: The study of coronary risk factors for atherosclerosis in women compares clinical, biochemical, and lifestyle factors in 200 consecutive pre- and postmenopausal women with incident coronary heart disease (CHD) to those in 255 age-matched population-based controls.

Results: Cases reported a higher intake of energy, predominantly through animal fat and protein reflected by a higher consumption of meat and sausage, while controls ate more fruit and vegetables. Multivariate analysis adjusted for clinical risk factors depicted a high intake of meat and sausage and a low consumption of fruit and vegetables as independent risk factors with an odds ratio of 2.5 (95% confidence interval 1.1-5.7) and 0.7 (95% confidence interval 0.5-1.0) for each 100 g per day, respectively. These dietary factors were found to be significantly more pronounced in cases with any clinical risk factor identified in this population as compared to controls with the same risk factors.

Conclusions: The CORA-study clearly indicates a major impact of dietary habits on CHD in women independent of, and additive to, that of conventional risk factors. Thus, in clinical practice, the potential of nutrition as part of a healthy lifestyle is commonly greatly underestimated in favour of drug treatment.

PubMed Disclaimer

Cited by

Periodontal Disease and Other Adverse Health Outcomes Share Risk Factors, including Dietary Factors and Vitamin D Status.
Grant WB, van Amerongen BM, Boucher BJ. Grant WB, et al. Nutrients. 2023 Jun 17;15(12):2787. doi: 10.3390/nu15122787. Nutrients. 2023. PMID: 37375691 Free PMC article. Review.
The Associations between Meat Group Consumption and Acute Myocardial Infarction Risks in an Iranian Population: a Case-Control Study.
Poursafar Z, Joukar F, Hasavari F, Atrkar Roushan Z. Poursafar Z, et al. Clin Nutr Res. 2019 Apr 26;8(2):159-168. doi: 10.7762/cnr.2019.8.2.159. eCollection 2019 Apr. Clin Nutr Res. 2019. PMID: 31089469 Free PMC article.
Food offerings on board and dietary intake of European and Kiribati seafarers - cross-sectional data from the seafarer nutrition study.
Zyriax BC, von Katzler R, Jagemann B, Westenhoefer J, Jensen HJ, Harth V, Oldenburg M. Zyriax BC, et al. J Occup Med Toxicol. 2018 Feb 27;13:9. doi: 10.1186/s12995-018-0190-0. eCollection 2018. J Occup Med Toxicol. 2018. PMID: 29988947 Free PMC article.
[Lipid-lowering therapy in the elderly : Who profits from which target values?].
Windler E, Beil FU, Klose G, Thiery J. Windler E, et al. Herz. 2018 May;43(3):230-237. doi: 10.1007/s00059-018-4686-2. Herz. 2018. PMID: 29569148 German.
[New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk : Statement of the D•A•CH Society for Prevention of Cardiovascular Diseases, the Austrian Atherosclerosis Society and the Working Group on Lipids and Atherosclerosis (AGLA) of the Swiss Society for Cardiology].
Klose G, Beil FU, Dieplinger H, von Eckardstein A, Föger B, Gouni-Berthold I, Koenig W, Kostner GM, Landmesser U, Laufs U, Leistikow F, März W, Merkel M, Müller-Wieland D, Noll G, Parhofer KG, Paulweber B, Riesen W, Schaefer JR, Steinhagen-Thiessen E, Steinmetz A, Toplak H, Wanner C, Windler E. Klose G, et al. Internist (Berl). 2014 May;55(5):601-6. doi: 10.1007/s00108-014-3492-z. Internist (Berl). 2014. PMID: 24770979 German.

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
- Ovid Technologies, Inc.
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program

Nutrition is a powerful independent risk factor for coronary heart disease in women--The CORA study: a population-based case-control study - PubMed (original) (raw)