Interleukin-1 and neuronal injury - PubMed (original) (raw)
Review
doi: 10.1038/nri1664.
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- PMID: 16034365
- DOI: 10.1038/nri1664
Review
Interleukin-1 and neuronal injury
Stuart M Allan et al. Nat Rev Immunol. 2005 Aug.
Abstract
Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including activation of many inflammatory processes (through activation of T cells, for example), induction of expression of acute-phase proteins, an important function in neuroimmune responses and direct effects on the brain itself. There is now extensive evidence to support the direct involvement of interleukin-1 in the neuronal injury that occurs in both acute and chronic neurodegenerative disorders. This article discusses the key evidence of a role for interleukin-1 in acute neurodegeneration - for example, stroke and brain trauma - and provides a rationale for targeting the interleukin-1 system as a therapeutic strategy.
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