Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition - PubMed (original) (raw)

Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

Catherine J Clark et al. Infect Immun. 2005 Aug.

Abstract

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hydroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.

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Figures

FIG. 1.

Schematic diagram of the kynurenine pathway illustrating the site of action of Ro-61-8048. The conversion from tryptophan to formylkynurenine is performed by tryptophan-2,3-dioxygenase in the liver and by indoleamine-2,3-dioxygenase in most other tissues.

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