ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation - PubMed (original) (raw)
ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation
Matthew A Kennedy et al. Cell Metab. 2005 Feb.
Free article
Abstract
Here we demonstrate that the ABC transporter ABCG1 plays a critical role in lipid homeostasis by controlling both tissue lipid levels and the efflux of cellular cholesterol to HDL. Targeted disruption of Abcg1 in mice has no effect on plasma lipids but results in massive accumulation of both neutral lipids and phospholipids in hepatocytes and in macrophages within multiple tissues following administration of a high-fat and -cholesterol diet. In contrast, overexpression of human ABCG1 protects murine tissues from dietary fat-induced lipid accumulation. Finally, we show that cholesterol efflux to HDL specifically requires ABCG1, whereas efflux to apoA1 requires ABCA1. These studies identify Abcg1 as a key gene involved in both cholesterol efflux to HDL and in tissue lipid homeostasis.
Comment in
- ABCG1: how critical for cholesterol transport?
Shachter NS. Shachter NS. Cell Metab. 2005 Feb;1(2):87-8. doi: 10.1016/j.cmet.2005.01.009. Cell Metab. 2005. PMID: 16054048
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