Baker yeast-induced fever in young rats: characterization and validation of an animal model for antipyretics screening - PubMed (original) (raw)
Comparative Study
. 2005 Aug 30;147(1):29-35.
doi: 10.1016/j.jneumeth.2005.03.002. Epub 2005 Apr 25.
Daiana Silva Avila, Ana Paula Oliveira Ferreira, Juliana Saibt Martins, Fabiane Rosa Souza, Carine Royer, Maribel Antonello Rubin, Marlí Redin Oliveira, Hélio Gauze Bonacorso, Marcos Antônio Pinto Martins, Nilo Zanatta, Carlos Fernando Mello
Affiliations
- PMID: 16054514
- DOI: 10.1016/j.jneumeth.2005.03.002
Comparative Study
Baker yeast-induced fever in young rats: characterization and validation of an animal model for antipyretics screening
Jorgete Tomazetti et al. J Neurosci Methods. 2005.
Abstract
In this study we describe a low-cost and reliable method for inducing fever in young male rats (28-30 days of age, 75-90 g), which seems suitable for the screening of new antipyretics. The effects of temperature measuring procedure-induced stress on the basal rectal temperature and on Baker yeast-induced hyperthermia was assessed. Rectal temperature (T) was recorded every hour for 12 h (07:00-19:00 h) with a lubricated thermistor probe. The animals were injected intraperitoneally with baker yeast (0.25, 0.135, 0.05 g/kg) or the equivalent volume of saline at 7:00 h. The administration of 0.135 g/kg baker yeast induced a sustained increase in rectal temperature for 4 h. Classical (dipyrone and acetaminophen) and novel (MPCA and FPCA) antipyretics, at doses that had no effect per se, reverted baker yeast-induced fever. The method presented induces a clear-cut fever, which is reverted by antipyretics commonly used in human beings and selected novel antipyretics in small animals. The method also allows antipyretic evaluation with low amount of drugs, due to the use of small animals and to the small variability of the pyretic response, which ultimately causes a significant reduction in the number of animals necessary for antipyretic evaluation. Therefore, this study describes an animal model of fever that is not only advantageous from the economical and technical point of view, but that also bears ethical concerns.
Similar articles
- Evaluation of antipyretic potential of Leucas lavandulaefolia (Labiatae) aerial part extract.
Mukherjee K, Saha BP, Mukherjee PK. Mukherjee K, et al. Phytother Res. 2002 Nov;16(7):686-8. doi: 10.1002/ptr.1013. Phytother Res. 2002. PMID: 12410556 - Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract.
Yam MF, Ang LF, Basir R, Salman IM, Ameer OZ, Asmawi MZ. Yam MF, et al. Inflammopharmacology. 2009 Feb;17(1):50-4. doi: 10.1007/s10787-008-8038-3. Inflammopharmacology. 2009. PMID: 19127348 - Evaluation of salicin as an antipyretic prodrug that does not cause gastric injury.
Akao T, Yoshino T, Kobashi K, Hattori M. Akao T, et al. Planta Med. 2002 Aug;68(8):714-8. doi: 10.1055/s-2002-33792. Planta Med. 2002. PMID: 12221594 - Management of childhood fever by parents: literature review.
Walsh A, Edwards H. Walsh A, et al. J Adv Nurs. 2006 Apr;54(2):217-27. doi: 10.1111/j.1365-2648.2006.03802.x. J Adv Nurs. 2006. PMID: 16553708 Review. - Endogenous antipyretics.
Roth J. Roth J. Clin Chim Acta. 2006 Sep;371(1-2):13-24. doi: 10.1016/j.cca.2006.02.013. Epub 2006 Mar 6. Clin Chim Acta. 2006. PMID: 16549059 Review.
Cited by
- Antiplasmodial and Antipyretic Activity and Safety Evaluation of the Methanolic Leaf Extract of Murraya exotica (L.).
Forkuo AD, Mensah KB, Ameyaw EO, Antwi AO, Kusi-Boadum NK, Ansah C. Forkuo AD, et al. J Parasitol Res. 2020 Aug 5;2020:1308541. doi: 10.1155/2020/1308541. eCollection 2020. J Parasitol Res. 2020. PMID: 32832131 Free PMC article. - Pharmacokinetic-pharmacodynamic modeling of the inhibitory effects of naproxen on the time-courses of inflammatory pain, fever, and the ex vivo synthesis of TXB2 and PGE2 in rats.
Krekels EH, Angesjö M, Sjögren I, Möller KA, Berge OG, Visser SA. Krekels EH, et al. Pharm Res. 2011 Jul;28(7):1561-76. doi: 10.1007/s11095-011-0389-6. Epub 2011 Feb 23. Pharm Res. 2011. PMID: 21347567 - In vivo evaluation of antipyretic effects of some homeopathic ultra-high dilutions on Baker's yeast-induced fever on Similia principle.
Ahmad S, Rehman T, Abbasi WM. Ahmad S, et al. J Ayurveda Integr Med. 2018 Jul-Sep;9(3):177-182. doi: 10.1016/j.jaim.2017.05.007. Epub 2017 Dec 6. J Ayurveda Integr Med. 2018. PMID: 29203352 Free PMC article. - Pharmacological evidence for the use of Cissus assamica as a medicinal plant in the management of pain and pyrexia.
Dutta T, Paul A, Majumder M, Sultan RA, Emran TB. Dutta T, et al. Biochem Biophys Rep. 2019 Dec 9;21:100715. doi: 10.1016/j.bbrep.2019.100715. eCollection 2020 Mar. Biochem Biophys Rep. 2019. PMID: 31872083 Free PMC article. - Integrating in vivo and in silico approaches to investigate the potential of Zingiber roseum rhizome extract against pyrexia, inflammation and pain.
Naiemur Rahman M, Shahin Ahmed K, Ahmed S, Hossain H, Shahid Ud Daula A. Naiemur Rahman M, et al. Saudi J Biol Sci. 2023 Apr;30(4):103624. doi: 10.1016/j.sjbs.2023.103624. Epub 2023 Mar 9. Saudi J Biol Sci. 2023. PMID: 36970254 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical