[Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats] - PubMed (original) (raw)

[Article in Russian]

PMID: 16075680

Comparative Study

[Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats]

[Article in Russian]

A Zh Fursova et al. Adv Gerontol. 2005.

Abstract

Cataracts and macular degeneration remain the major cause of blindness and acuity of vision deterioration in the elderly. Both pathology have been attributed to damage by free radicals, there has been a great deal of interest in antioxidants. Bilberry's flavonoids are known as potent antioxidants, scavenging free radicals and used for multiple age-releted ocular disorders. There are no experimental studies, devoted to estimation of bilberry effect. To explore this one the senescence-accelerated OXYS rats with early senile cataract and macular degeneration were used. From 1.5 to 3 month OXYS rats were given control diets or those supplemented with 25% bilberry extract (BE, 20 mg on kg of body weight including 4.5 mg of antocianidin) or vitamin E (40 mg/kg) as drag for comparison. The testing at 3 month have showed that more then 70% of control OXYS rats had cataract and macular degeneration while the supplementation of BE completely prevented impairments in the lenses and retina. The VE had no significant effects but both antioxidants decreased lipid peroxides in the retina and serum of OXYS rats. The results suggest that the OXYS rat strain is the useful model for macular degeneration and senile cataract and long-term supplementation with BE is effective in prevention of macular degeneration and cataract.

PubMed Disclaimer

Cited by

Review of Evidence for the Usage of Antioxidants for Eye Aging.
Choo PP, Woi PJ, Bastion MC, Omar R, Mustapha M, Md Din N. Choo PP, et al. Biomed Res Int. 2022 Oct 3;2022:5810373. doi: 10.1155/2022/5810373. eCollection 2022. Biomed Res Int. 2022. PMID: 36225983 Free PMC article. Review.
Inherited Retinal Dystrophies: Role of Oxidative Stress and Inflammation in Their Physiopathology and Therapeutic Implications.
Pinilla I, Maneu V, Campello L, Fernández-Sánchez L, Martínez-Gil N, Kutsyr O, Sánchez-Sáez X, Sánchez-Castillo C, Lax P, Cuenca N. Pinilla I, et al. Antioxidants (Basel). 2022 May 30;11(6):1086. doi: 10.3390/antiox11061086. Antioxidants (Basel). 2022. PMID: 35739983 Free PMC article. Review.
A Re-Appraisal of Pathogenic Mechanisms Bridging Wet and Dry Age-Related Macular Degeneration Leads to Reconsider a Role for Phytochemicals.
Pinelli R, Biagioni F, Limanaqi F, Bertelli M, Scaffidi E, Polzella M, Busceti CL, Fornai F. Pinelli R, et al. Int J Mol Sci. 2020 Aug 3;21(15):5563. doi: 10.3390/ijms21155563. Int J Mol Sci. 2020. PMID: 32756487 Free PMC article. Review.
Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration.
Bosch-Morell F, Villagrasa V, Ortega T, Acero N, Muñoz-Mingarro D, González-Rosende ME, Castillo E, Sanahuja MA, Soriano P, Martínez-Solís I. Bosch-Morell F, et al. Neural Regen Res. 2020 Dec;15(12):2207-2216. doi: 10.4103/1673-5374.284978. Neural Regen Res. 2020. PMID: 32594032 Free PMC article. Review.
Recent Research on the Health Benefits of Blueberries and Their Anthocyanins.
Kalt W, Cassidy A, Howard LR, Krikorian R, Stull AJ, Tremblay F, Zamora-Ros R. Kalt W, et al. Adv Nutr. 2020 Mar 1;11(2):224-236. doi: 10.1093/advances/nmz065. Adv Nutr. 2020. PMID: 31329250 Free PMC article. Review.

[Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senesce-accelerated OXYS rats] - PubMed (original) (raw)