Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis - PubMed (original) (raw)
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doi: 10.1038/nrc1693.
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- DOI: 10.1038/nrc1693
Review
Opinion: emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis
Yihai Cao. Nat Rev Cancer. 2005 Sep.
Abstract
Malignant tumours can spread to lymph nodes through lymphatic vessels. Recent studies show that tumours produce a range of growth factors that directly or indirectly stimulate lymphatic vessel growth (lymphangiogenesis) and lymphatic metastasis. These findings indicate that tumour lymphangiogenesis, similar to haemangiogenesis, is a complex process that is regulated by multiple growth factors. Understanding the underlying mechanisms by which tumours induce lymphangiogenesis might provide important information for the therapeutic intervention of metastatic spread.
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