Ran-GTP regulates kinetochore attachment in somatic cells - PubMed (original) (raw)
Review
doi: 10.4161/cc.4.9.1979. Epub 2005 Sep 28.
Affiliations
- PMID: 16082212
- DOI: 10.4161/cc.4.9.1979
Review
Ran-GTP regulates kinetochore attachment in somatic cells
Alexei Arnaoutov et al. Cell Cycle. 2005 Sep.
Abstract
The Ran GTPase controls multiple mitotic processes in Xenopus egg extracts, including mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. We have analyzed Ran's role in somatic cells. We uncovered a novel mitotic role of Ran-GTP, involving the Crm1 nuclear export receptor. This pathway is an important mode of Ran-GTP function during mitosis in mammalian somatic cells, which mediates the recruitment of the RanGAP1/RanBP2 complex to kinetochores and maintains the microtubule-based fibers connecting kinetochores to spindle poles (k-fibers). Here we discuss potential implications of these findings for normal k-fiber assembly.
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