The spindle checkpoint: tension versus attachment - PubMed (original) (raw)
Review
The spindle checkpoint: tension versus attachment
Benjamin A Pinsky et al. Trends Cell Biol. 2005 Sep.
Abstract
The spindle checkpoint ensures the fidelity of chromosome segregation by preventing cell-cycle progression until all the chromosomes make proper bipolar attachments to the mitotic spindle and come under tension. Despite significant advances in our understanding of spindle checkpoint function, the primary signal that activates the spindle checkpoint remains unclear. Whereas some experiments indicate that the checkpoint recognizes the lack of microtubule attachment to the kinetochore, others indicate that the checkpoint senses the absence of tension generated on the kinetochore by microtubules. The interdependence between tension and microtubule attachment make it difficult to determine whether these signals are separable. In this article (which is part of the Chromosome Segregation and Aneuploidy series), we consider recent evidence that supports and opposes the hypothesis that defects in tension act as the primary checkpoint signal.
Similar articles
- The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.
Pinsky BA, Kung C, Shokat KM, Biggins S. Pinsky BA, et al. Nat Cell Biol. 2006 Jan;8(1):78-83. doi: 10.1038/ncb1341. Epub 2005 Dec 4. Nat Cell Biol. 2006. PMID: 16327780 - A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes.
Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW. Dorer RK, et al. Curr Biol. 2005 Jun 7;15(11):1070-6. doi: 10.1016/j.cub.2005.05.020. Curr Biol. 2005. PMID: 15936280 - Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast.
Gillett ES, Espelin CW, Sorger PK. Gillett ES, et al. J Cell Biol. 2004 Feb 16;164(4):535-46. doi: 10.1083/jcb.200308100. Epub 2004 Feb 9. J Cell Biol. 2004. PMID: 14769859 Free PMC article. - Sister chromatid tension and the spindle assembly checkpoint.
Nezi L, Musacchio A. Nezi L, et al. Curr Opin Cell Biol. 2009 Dec;21(6):785-95. doi: 10.1016/j.ceb.2009.09.007. Epub 2009 Oct 19. Curr Opin Cell Biol. 2009. PMID: 19846287 Review. - Bi-orienting chromosomes on the mitotic spindle.
Tanaka TU. Tanaka TU. Curr Opin Cell Biol. 2002 Jun;14(3):365-71. doi: 10.1016/s0955-0674(02)00328-9. Curr Opin Cell Biol. 2002. PMID: 12067660 Review.
Cited by
- Low tension recruits the yeast Aurora B protein Ipl1 to centromeres in metaphase.
Edgerton HD, Mukherjee S, Johansson M, Bachant J, Gardner MK, Clarke DJ. Edgerton HD, et al. J Cell Sci. 2023 Aug 15;136(16):jcs261416. doi: 10.1242/jcs.261416. Epub 2023 Aug 17. J Cell Sci. 2023. PMID: 37519149 Free PMC article. - Robust microtubule dynamics facilitate low-tension kinetochore detachment in metaphase.
Parmar S, Gonzalez SJ, Heckel JM, Mukherjee S, McClellan M, Clarke DJ, Johansson M, Tank D, Geisness A, Wood DK, Gardner MK. Parmar S, et al. J Cell Biol. 2023 Aug 7;222(8):e202202085. doi: 10.1083/jcb.202202085. Epub 2023 May 11. J Cell Biol. 2023. PMID: 37166419 Free PMC article. - Three interacting regions of the Ndc80 and Dam1 complexes support microtubule tip-coupling under load.
Flores RL, Peterson ZE, Zelter A, Riffle M, Asbury CL, Davis TN. Flores RL, et al. J Cell Biol. 2022 May 2;221(5):e202107016. doi: 10.1083/jcb.202107016. Epub 2022 Mar 30. J Cell Biol. 2022. PMID: 35353161 Free PMC article. - Centromere Tension Measurement in Budding Yeast Mitosis.
Mukherjee S, Gardner MK. Mukherjee S, et al. Methods Mol Biol. 2022;2415:199-210. doi: 10.1007/978-1-0716-1904-9_15. Methods Mol Biol. 2022. PMID: 34972956 Free PMC article. - Attenuated Chromosome Oscillation as a Cause of Chromosomal Instability in Cancer Cells.
Iemura K, Yoshizaki Y, Kuniyasu K, Tanaka K. Iemura K, et al. Cancers (Basel). 2021 Sep 9;13(18):4531. doi: 10.3390/cancers13184531. Cancers (Basel). 2021. PMID: 34572757 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases