Contributions of low molecule number and chromosomal positioning to stochastic gene expression - PubMed (original) (raw)
doi: 10.1038/ng1616. Epub 2005 Aug 7.
Affiliations
- PMID: 16086016
- DOI: 10.1038/ng1616
Contributions of low molecule number and chromosomal positioning to stochastic gene expression
Attila Becskei et al. Nat Genet. 2005 Sep.
Abstract
The presence of low-copy-number regulators and switch-like signal propagation in regulatory networks are expected to increase noise in cellular processes. We developed a noise amplifier that detects fluctuations in the level of low-abundance mRNAs in yeast. The observed fluctuations are not due to the low number of molecules expressed from a gene per se but originate in the random, rare events of gene activation. The frequency of these events and the correlation between stochastic expressions of genes in a single cell depend on the positioning of the genes along the chromosomes. Transcriptional regulators produced by such random expression propagate noise to their target genes.
Comment in
- Prime movers of noisy gene expression.
Paulsson J. Paulsson J. Nat Genet. 2005 Sep;37(9):925-6. doi: 10.1038/ng0905-925. Nat Genet. 2005. PMID: 16132049 No abstract available.
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